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Diagnostic Accuracy of Chinese Medicine Diagnosis Scale of Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: A Study Protocol

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Abstract

Background

Phlegm and blood stasis syndrome (PBSS) is one of the main syndromes in coronary heart disease (CHD). Syndromes of Chinese medicine (CM) are lack of quantitative and easy-implementation diagnosis standards. To quantify and standardize the diagnosis of PBSS, scales are usually applied.

Objective

To evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD.

Methods

Six hundred patients with stable angina pectoris of CHD, 300 in case group and 300 in control group, will be recruited from 5 hospitals across China. Diagnosis from 2 experts will be considered as the “gold standard”. The study design consists of 2 phases: pilot test is used to evaluate the reliability and validity, and diagnostic test is used to assess the diagnostic accuracy of the scale, including sensitivity, specificity, likelihood ratio and area under the receiver operator characteristic (ROC) curve.

Discussion

This study will evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD. The consensus of 2 experts may not be ideal as a “gold standard”, and itself still requires further study. (No. ChiCTR-OOC-15006599).

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Authors and Affiliations

  1. School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China

    Xiao-qi Liu, Dan-hong Peng, Yan-ping Wang, Rong Xie, Xin-lin Chen & Xian-tao Li

  2. Journal Editorial Board, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

    Chun-quan Yu

Authors
  1. Xiao-qi Liu
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  2. Dan-hong Peng
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  3. Yan-ping Wang
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  4. Rong Xie
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  5. Xin-lin Chen
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  6. Chun-quan Yu
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  7. Xian-tao Li
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Corresponding author

Correspondence to Xian-tao Li.

Additional information

Supported by National Basic Research Program of China (973 Program, No. 2014CB542901)

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Liu, Xq., Peng, Dh., Wang, Yp. et al. Diagnostic Accuracy of Chinese Medicine Diagnosis Scale of Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: A Study Protocol. Chin. J. Integr. Med. 25, 515–520 (2019). https://doi.org/10.1007/s11655-018-2793-9

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  • DOI: https://doi.org/10.1007/s11655-018-2793-9

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