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Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory

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Abstract

Objective

To investigate the relationship between tissue distributions of modified Wuzi Yanzong prescription (加味五子衍宗方, MWP) in rats and meridian tropism theory.

Methods

A high-performance liquid chromatography with Fourier transform-mass spectrometry (HPLC-FT) method was used to identify the metabolites of MWP in different tissues of rats after continued oral administration of MWP for 7 days. The relationship between MWP and meridian tropism theory was studied according to the tissue distributions of the metabolites of MWP in rats and the relevant literature.

Results

Nineteen metabolites, mainly flavanoid compounds, were detected in the different rat tissues and classified to each herb in MWP. Further, it was able to establish that the tissue distributions of the metabolites of MWP were consistent with the descriptions of meridian tropism of MWP available in literature, this result might be useful in clarifying the mechanism of MWP on meridian tropism. In the long run, these data might provide scientific evidence of the meridian tropism theory to further promote the reasonable, effective utilization, and modernization of Chinese medicine.

Conclusion

The tissue distributions of MWP in vivo were consistent with the descriptions of meridian tropism of MWP.

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Authors and Affiliations

  1. Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, 100034, China

    Lin-lin Wang, Wei-wei Li, Yi-xiang Song, Fang-jiao Song, Hong Fu, Geng-xin Liu & Xue-mei Wang

  2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Cai-sheng Wu & Jin-lan Zhang

Authors
  1. Lin-lin Wang
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  2. Wei-wei Li
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  3. Cai-sheng Wu
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  4. Jin-lan Zhang
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  5. Yi-xiang Song
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  6. Fang-jiao Song
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  7. Hong Fu
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  8. Geng-xin Liu
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  9. Xue-mei Wang
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Corresponding author

Correspondence to Xue-mei Wang.

Additional information

Supported by the National Natural Science Foundation of China (Nos. 81102683, 30973813 and 81173369), the Doctoral Fund of the Ministry of Education of China (Nos. 20110001120055 and 20120001110105), and the Natural Science Foundation of Beijing City (No. 7132210)

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Wang, Ll., Li, Ww., Wu, Cs. et al. Relationship between Tissue Distributions of Modified Wuzi Yanzong Prescription (加味五子衍宗方) in Rats and Meridian Tropism Theory. Chin. J. Integr. Med. 24, 117–124 (2018). https://doi.org/10.1007/s11655-016-2270-2

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  • DOI: https://doi.org/10.1007/s11655-016-2270-2

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