Skip to main content
SpringerLink
Log in

Effect of Shuwei Decoction (舒胃汤) on rats with functional dyspepsia

  • Original Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To investigate the effects of Shuwei Decoction (舒胃汤, SWD) on gastric emptying, serum stem cell factor (SCF), the content of serum nitric oxide (NO), and structure change of interstitial cells of Cajal (ICC) in functional dyspepsia (FD) rats.

Methods

Sixty Sprague Dawley rats were randomly divided into 6 groups: blank group (group A), model group (group B), mosapride group (group C), Muxiang Shunqi Pill (木香顺气丸, MSP) group (group D), SWD low-dose group (group E), and SWD high-dose group (group F), 10 rats in each group. FD rat model was established by clasping rats’ tails for 7 days, except the group A. After 3 days, group A and group B were given distilled water, and the medicated rats were given corresponding medicine for 14 days. The gastric emptying, structure change of ICC in gastric antrum by transmission electron microscope, the content of serum NO by nitrate reductant and SCF by enzyme linked immunosorbent assay were observed.

Results

Compared with group A, the rats in group B delayed gastric emptying, serum SCF decreased, serum NO increased (P <0.05). Compared with group B, the rats in groups D, E and F were improved on gastric emptying, obviously increased on serum SCF, decreased on serum NO (P <0.05), and structure change of ICC in gastric antrum improved. Compared with group B, structure change of ICC of group E after treatment was improved and was closed to group A.

Conclusion

SWD recovered gastrointestinal motility of FD, possibly by regulating the levels of serum NO and SCF, and improving the structure of ICC in gastric antrum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol 2006;12:2661–2666.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Xin C. Observation of mosapride and doxepine associated therapy for functional dyspepsia 61 cases. Chongqing Med J (Chin) 2007;36:2334,2343.

    Google Scholar 

  3. Wang Y. Observation on effect of trimebutine and digestive enzymes compound associated therapy for functional dyspepsia. Chin Gene Pract (Chin) 2009;12:415–416.

    CAS  Google Scholar 

  4. Zhang XG, Hu PJ, Lin JK, Yue DC, Peng XZ. Gastric sensorimotor function in patients with functional dyspepsia. Chin J Digest (Chin) 2003;23:227–229.

    CAS  Google Scholar 

  5. Tan HL, Wang XJ. Clinical observation of Shuwei Decoction in the treatment of the type of Liver-Stomach disharmony functional dyspepsia 30 cases. Chin J Exp Tradit Med Formul (Chin) 2009;15:93–94.

    Google Scholar 

  6. Hu SJ, Wang XJ, Guo X, Xiao L, Tan HL. Effect of Shuwei Decoction on motilin expression in interstitial cells of Cajal of functional dyspepsia rats. Chin J Exp Tradit Med Formu (Chin) 2011;17:170–173.

    Google Scholar 

  7. Hu SJ, Wang XJ, Guo X, Xiao L, Liu Y, Qu B. Effect of Shuwei Decoction on the expression of interstitial cells of Cajal and substance P of functional dyspepsia rats. Chin J Inf Tradit Chin Med (Chin) 2010;17:30–31.

    Google Scholar 

  8. Guo HJ, Lin J, Li GC, Li YB, Tao XL, Luo SX. The animal model study of functional dyspepsia. Chin J Integr Tradit West Med Digest (Chin) 2001;9:141–142.

    Google Scholar 

  9. Takayama I, Horiguchi K, Daigo Y, Mine T, Fujino MA, Ohno S. The interstitial cells of Cajal and a gastroenteric pacemaker system. Arch Histol Cytol 2002;65:1–26.

    Article  PubMed  Google Scholar 

  10. Long QL, Fang DC, Shi HT, Xiang GC, Luo YH. Effects of interstitial cells of Cajal in stomach on diabetic gastroparesis. Chongqing Med J (Chin) 2005;34:1159–1160, 1163.

    Google Scholar 

  11. Liu S. Cajal interstitial cell of gastrointestinal tract. Chin J Clin Gastroenterol (Chin) 2009;21:104–105.

    CAS  Google Scholar 

  12. Takayama I, Horiguchi K, Daigo Y, Mine T, Fujino MA, Ohno S. The interstitial cells of Cajal and a gastroenteric pacemaker system. Arch Histol Cytol 2002;65:1–26.

    Article  PubMed  Google Scholar 

  13. Wang ZY, Xu WX. The latest study on pacing function of gastrointestinal smooth muscle. World Chin J Digest (Chin) 2010;18:319–323.

    Google Scholar 

  14. Zhang D, Xia ZW, Han YJ. The effect of different duration of chronic restraint immersion stress on the ultrastructure of interstitial cells of Cajal in the antrum of rats. World Chin J Digest (Chin) 2010;18:581–585.

    Google Scholar 

  15. Battaglia E, Bassotti G, Bellone G, Dughera L, Serra AM, Chiusa L, et al. Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis. World J Gastroenterol 2006;12:6172–6177.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Zhang H, Xu X, Wang Z, Li C, Ke M. Correlation between gastric myoelectrical activity recorded by multi-channel electrogastrography and gastric emptying in patients with functional dyspepsia. Scand J Gastroenterol 2006;41:797–804.

    Article  CAS  PubMed  Google Scholar 

  17. Sanders KM, Ward SM. Interstitial cells of Cajal: a new perspective on smooth muscle function. J Physiol 2006;576:721–726.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Gong YS. Stem cel l factor and substance P in gastrointestinal motility disorders in diabetic rat colon carcinoma and rhubarb to its impact and interventions. Jiangxi Med (Chin) 2009;44:879–881.

    Google Scholar 

  19. Yu Y, Wang QM. Progress in Stem cell and gastrointestinal motility. Inter J Gastroenter ol 2008;28:302–305.

    CAS  Google Scholar 

  20. Long QL, Fang DC, Shi HT, Xiang GC, Luo YY. Change of c-kit/SCF signaling system and its effect on interstitical cells in gastric of diabetic rats. Acta Acad Med Milit Tertiae 2007;29:141–143.

    CAS  Google Scholar 

  21. Xu LM, Lin L, Tang YR, Zhang HJ, Li XL. Stem cell factor influence in diabetes, colon interstitial cells of Cajal. Chin J Digest (Chin) 2008;28:388–391.

    CAS  Google Scholar 

  22. Xu LM, Lin L, Tang YR, Zhang HJ, Li XL. Stem cell factor on diabetic mice colonic interstitial cells of Cajal of the intervention effect. World J Gastroenter ol 2008;16:1294–1298.

    CAS  Google Scholar 

  23. Shi YD, Liang LL, Chen SN. Stomachache Xiaopi Decoction experimental study on Nitric oxide and gastrin in rats with functional dyspepsia. Pract Med Clin (Chin) 2010;13:86–87.

    Google Scholar 

  24. Malmström RE, Björne H, Oldner A, Wanecek M, Fredriksson M, Lundberg JO, et al. Intestinal nitric oxide in the normal and endotoxemic pig. Shock 2002;18:456–460.

    Article  PubMed  Google Scholar 

  25. Dong YP, Qu KY, Li WS, Guo LJ. Auriculate cynanchum tuber impact on nitric oxide and the cholinesterase in rats with functional dyspepsia. Mod J Integr Med 2005;14:23–24.

    Google Scholar 

  26. Takahashi T, Owyang C. Vagal control of nitric oxide and vasoactive intestinal polypeptide release in the regulation of gastric relaxation in rat. J Physiol 1995;484:481–492.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Ward SM, Sanders KM. Interst it ial cells of Cajal: primary targets of enteric motor innervation. Anat Rec 2001;262:125–135.

    Article  CAS  PubMed  Google Scholar 

  28. Koh SD, Kim TW, Jun JY, Glasgow NJ, Ward SM, Sanders KM. Regulation of pacemaker currents in interstitial cells of Cajal from murine small intestine by cyclic nucleotides. J Physiol 2000;527:149–162.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Ward SM, Brennan MF, Jackson VM, Sanders KM. Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle. J Physiol 1999;516:835–846.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, 410007, China

    Xiao-juan Wang  (王小娟)

  2. College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha, 410007, China

    Jian-sheng Guo  (郭建生)

  3. Graduate College, Hunan University of Traditional Chinese Medicine, Changsha, 410007, China

    Yin Xu  (徐 寅), Xuan Guo  (郭 璇), Yan-hong Mi  (弭艳红), Jiao Yin  (尹 姣), Zhong-hua Du  (杜中华) & Li-ming Zhang  (张丽明)

Authors
  1. Xiao-juan Wang  (王小娟)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jian-sheng Guo  (郭建生)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yin Xu  (徐 寅)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xuan Guo  (郭 璇)
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yan-hong Mi  (弭艳红)
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jiao Yin  (尹 姣)
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zhong-hua Du  (杜中华)
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Li-ming Zhang  (张丽明)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jian-sheng Guo  (郭建生).

Additional information

Supported by the National Natural Science Foundation of China (No. 81373577), Scientific Research Foundation of Traditional Chinese Medicine of Hunan Provincial Health Department (No. 2008025), and the Foundation of Changsha Science and Technology Commission (No. K1001061-31)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, Xj., Guo, Js., Xu, Y. et al. Effect of Shuwei Decoction (舒胃汤) on rats with functional dyspepsia. Chin. J. Integr. Med. (2016). https://doi.org/10.1007/s11655-015-2403-z

Download citation

  • Received:

  • Published:

  • DOI: https://doi.org/10.1007/s11655-015-2403-z

Keywords

Search

Navigation