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Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix

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Abstract

There has been a constant requirement from the clinic to develop biomedical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells (hB-MSCs) by activating ERK1/2-miR-1827-Osterix signaling pathway in vitro. MAO surface of titanium implant was more favorable to promote osteogenic differentiation than SLA and AOS coating. Besides, titanium implants regulated hB-MSCs osteogenesis through the p38 MAPK pathway and ERK1/2 might be the most efficient target. Furthermore, MAO coating induced osteogenic differentiation though ERK1/2-miR-1827 pathway. Finally, we verified miR-1827 regulated osteogenic differentiation partially through Osterix. Our study reveals novel insights that MAO surface of titanium implant is a prior choice for biomedical trial and for its use in periprosthetic osteolysis (PIO) treatment in an evidence-based rationale.

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Data availability statement

The authors declare all of the data are available.

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Acknowledgments

We thank The First Affiliated Hospital, Fujian Medical University, for the capital and equipment support.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Laboratory of Facial Plastic and Reconstruction, Fujian Medical University, No. 20, Chazhong Road, Fuzhou, 350005, Fujian, China

    Liu Liu, Yunyang Liao & Bin Shi

  2. School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian, China

    Liu Liu

  3. Xiamen Medical Device Research & Testing center, Xiamen, Fujian, China

    Da Zeng & Yanwen Chen

  4. Department of stomatology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China

    Junbo Zhou

Authors
  1. Liu Liu
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  2. Da Zeng
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  3. Yanwen Chen
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  4. Junbo Zhou
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  5. Yunyang Liao
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  6. Bin Shi
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Correspondence to Bin Shi.

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Editor: Tetsuji Okamoto

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Liu, L., Zeng, D., Chen, Y. et al. Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix. In Vitro Cell.Dev.Biol.-Animal 56, 296–306 (2020). https://doi.org/10.1007/s11626-020-00444-7

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  • DOI: https://doi.org/10.1007/s11626-020-00444-7

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