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Assessment of radiation dermatitis using objective analysis for patients with breast cancer treated with breast-conserving therapy: influence of body weight

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Abstract

Purpose

To evaluate the effect of patient factors on radiation dermatitis for patients with breast cancer who underwent postoperative radiotherapy after breast-conserving surgery.

Materials and methods

The study population comprised 87 patients who underwent breast-conserving surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost radiation (10 Gy/5 fractions). We examined their treated and contralateral breast skin color by use of an objective analyzer, and expressed findings as L*, a*, b* ratios by dividing by pre-RT values. Next, we examined correlation between patient factors (age, height, body weight, and body mass index, BMI) and change of L* and a* values by use of correlation coefficients.

Results

Radiation therapy caused changes in a* and L* ratios (p < 0.0001) but not in b* ratio. The a* ratio (reddish) increased 1.4-fold and peaked after radiotherapy. The L* ratio (darkening) decreased by 10 % and reached a minimum value between completion of radiotherapy and 1 month after treatment. Although, age and height did not affect Δ value, body weight and BMI correlated significantly with Δa* value (p = 0.0012 and 0.0017) not with ΔL* value.

Conclusion

Body weight and BMI predict degree of radiation dermatitis, and more reddish dermatitis was observed for heavier patients than for their lighter counterparts.

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Authors and Affiliations

  1. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Hideya Yamazaki, Kana Kobayashi, Takuji Tsubokura, Naohiro Kodani, Norihiro Aibe, Hiroyasu Ikeno & Takuya Nishimura

  2. Department of Radiology, National Hospital Organization, Osaka National Hospital, Osaka, Japan

    Ken Yoshida

Authors
  1. Hideya Yamazaki
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  2. Ken Yoshida
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  3. Kana Kobayashi
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  4. Takuji Tsubokura
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  5. Naohiro Kodani
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  6. Norihiro Aibe
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  7. Hiroyasu Ikeno
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  8. Takuya Nishimura
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Corresponding author

Correspondence to Hideya Yamazaki.

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Yamazaki, H., Yoshida, K., Kobayashi, K. et al. Assessment of radiation dermatitis using objective analysis for patients with breast cancer treated with breast-conserving therapy: influence of body weight. Jpn J Radiol 30, 486–491 (2012). https://doi.org/10.1007/s11604-012-0073-8

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  • DOI: https://doi.org/10.1007/s11604-012-0073-8

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