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Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy

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Abstract

Purpose

We compared the radioresponse of cervical carcinoma that was closely related to local disease control by the tumor regression rate (RR) during intracavitary radiotherapy (ICRT) and external beam radiotherapy (EBRT) on the presumption that ICRT has a stronger treatment impact than EBRT because of its specific dose distribution.

Materials and methods

A total of 37 patients were treated by EBRT at 45.0 Gy over 5 weeks, followed by high-dose-rate ICRT at 6.0 Gy per weekly insertion at point A three to five times and by boost EBRT. RR was defined as the slope (day−1) of the tumor-volume shrinkage curve fit to an exponential regression equation. Assuming that the tumors were ellipsoid, the tumor volume was estimated using magnetic resonance (MR) images obtained before treatment, after 45.0 Gy of EBRT, and after the third ICRT insertion. RRs were compared based on the radiotherapy method.

Results

RR ranged between −0.008 to 0.093 day−1 (median 0.021 day−1) during EBRT and −0.001 to 0.097 day−1 (median 0.018 day−1) during ICRT, showing no significant difference or correlation between treatments.

Conclusion

Contrary to expectations, RR did not directly relate to the impact of physical treatment. RR could be related to biological factors, such as the amount of tumor clearance and changes in tumor consistency during treatment.

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Author notes

  1. Kiyoshi Ohara

    Present address: Department of Radiation Oncology, Tsuchiura Kyodo General Hospital, 11-7 Manabeshinmachi, Tsuchiura, 300-0053, Japan

Authors and Affiliations

  1. Department of Radiation Oncology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

    Kiyoshi Ohara

  2. Department of Diagnostic Radiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

    Yumiko Oishi Tanaka & Yoshikazu Okamoto

  3. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

    Akinori Oki, Toyomi Satoh, Koji Matsumoto & Hiroyuki Yoshikawa

Authors
  1. Kiyoshi Ohara
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  2. Yumiko Oishi Tanaka
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  3. Akinori Oki
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  4. Yoshikazu Okamoto
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  5. Toyomi Satoh
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  6. Koji Matsumoto
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  7. Hiroyuki Yoshikawa
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Correspondence to Kiyoshi Ohara.

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Ohara, K., Tanaka, Y.O., Oki, A. et al. Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy. Radiat Med 26, 526–532 (2008). https://doi.org/10.1007/s11604-008-0268-1

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  • DOI: https://doi.org/10.1007/s11604-008-0268-1

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