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Functional computed tomography imaging of tumor-induced angiogenesis: preliminary results of new tracer kinetic modeling using a computer discretization approach

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Abstract

Purpose

The aim of this study was to establish functional computed tomography (CT) imaging as a method for assessing tumor-induced angiogenesis.

Materials and methods

Functional CT imaging was mathematically analyzed for 14 renal cell carcinomas by means of two-compartment modeling using a computer-discretization approach. The model incorporated diffusible kinetics of contrast medium including leakage from the capillary to the extravascular compartment and back-flux to the capillary compartment. The correlations between functional CT parameters [relative blood volume (rbv), permeability 1 (Pm1), and permeability 2 (Pm2)] and histopathological markers of angiogenesis [microvessel density (MVD) and vascular endothelial growth factor (VEGF)] were statistically analyzed.

Results

The modeling was successfully performed, showing similarity between the mathematically simulated curve and the measured time-density curve. There were significant linear correlations between MVD grade and Pm1 (r = 0.841, P = 0.001) and between VEGF grade and Pm2 (r = 0.804, P = 0.005) by Pearson’s correlation coefficient.

Conclusion

This method may be a useful tool for the assessment of tumor-induced angiogenesis.

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Authors and Affiliations

  1. Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Katsuhiko Kaneoya, Kouichi Isobe, Ken Motoori, Seiji Yamamoto & Hisao Ito

  2. Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Room S-072, Stanford, CA, 94305-5105, USA

    Takuya Ueda & Geoffrey D. Rubin

  3. Department of Environmental and Mathematical Science, Okayama University, Okayama, Japan

    Hiroshi Suito & Youhei Nanazawa

  4. Department of Pathology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan

    Junichi Tamaru

  5. Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Yukio Naya & Toyofusa Tobe

  6. Department of Radiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

    Manabu Minami

Authors
  1. Katsuhiko Kaneoya
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  2. Takuya Ueda
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  3. Hiroshi Suito
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  4. Youhei Nanazawa
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  5. Junichi Tamaru
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  6. Kouichi Isobe
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  7. Yukio Naya
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  8. Toyofusa Tobe
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  9. Ken Motoori
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  10. Seiji Yamamoto
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  11. Geoffrey D. Rubin
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  12. Manabu Minami
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  13. Hisao Ito
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Corresponding author

Correspondence to Takuya Ueda.

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Cite this article

Kaneoya, K., Ueda, T., Suito, H. et al. Functional computed tomography imaging of tumor-induced angiogenesis: preliminary results of new tracer kinetic modeling using a computer discretization approach. Radiat Med 26, 213–221 (2008). https://doi.org/10.1007/s11604-007-0217-4

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  • DOI: https://doi.org/10.1007/s11604-007-0217-4

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