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C-reactive Protein/Albumin Ratio as a Prognostic Indicator in Posttraumatic Shock and Outcome of Multiple Trauma Patients

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Abstract

Objective

C-reactive protein (CRP)/albumin ratio (CAR) is a new inflammation-based index for predicting the prognosis of various diseases. The CAR determined on admission may help to predict the prognostic value of multiple trauma patients.

Methods

A total of 264 adult patients with severe multiple trauma were included for the present retrospective study, together with the collection of relevant clinical and laboratory data. CAR, CRP, albumin, shock index and ISS were incorporated into the prognostic model, and the receiver operating characteristic (ROC) curve was drawn. Then, the shock index for patients with different levels of CAR was analyzed. Finally, univariate and multivariate logistic regression analyses were performed to identify the independent risk factors for the 28-day mortality of multiple trauma patients.

Results

A total of 36 patients had poor survival outcomes, and the mortality rate reached 13.6%. Furthermore, after analyzing the shock index for patients with different levels of CAR, it was revealed that the shock index was significantly higher when CAR was ≥4, when compared to CAR <2 and 2≤ CAR <4, in multiple trauma patients. The multivariate logistic analysis helped to identify the independent association between the variables CAR (P=0.029) and shock index (P=0.019), and the 28-day mortality of multiple trauma patients.

Conclusion

CAR is higher in patients with severe multiple trauma. Furthermore, CAR serves as a risk factor for independently predicting the 28-day mortality of multiple trauma patients. The shock index was significantly higher when CAR was ≥4 in multiple trauma patients.

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Author notes

  1. The authors contributed equally to this study.

Authors and Affiliations

  1. Emergency Department, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China

    Xin Lu, Wei-chen Liu, Yan Qin, Du Chen, Peng Yang, Xiong-hui Chen, Si-rong Wu & Feng Xu

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  1. Xin Lu
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  2. Wei-chen Liu
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  3. Yan Qin
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  4. Du Chen
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  5. Peng Yang
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  6. Xiong-hui Chen
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  7. Si-rong Wu
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  8. Feng Xu
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Corresponding author

Correspondence to Feng Xu.

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Conflict of Interest Statement

No conflict of interest exists in the submission of this manuscript.

This project was supported by Jiangsu Provincial Medical Innovation Center of Jiangsu Province Capability Improvement Project through Science, Technology and Education (No. CXZX202231), and the Special Research Topic on Innovation of Hospital Management, Jiangsu Provincial Hospital Association (No. JSYGY-3-2021-JZ71).

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Lu, X., Liu, Wc., Qin, Y. et al. C-reactive Protein/Albumin Ratio as a Prognostic Indicator in Posttraumatic Shock and Outcome of Multiple Trauma Patients. CURR MED SCI 43, 360–366 (2023). https://doi.org/10.1007/s11596-023-2714-9

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  • DOI: https://doi.org/10.1007/s11596-023-2714-9

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