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Feasibility of Subtraction Coronary Computed Tomographic Angiography and Influencing Factor Analysis: a Retrospective Study

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Abstract

Objective

To investigate the feasibility of subtraction coronary computed tomographic (CT) angiography (SubCCTA) to decline calcium artifacts and improve diagnostic accuracy in the presence of coronary calcification and analyze the factors that influence SubCCTA.

Methods

A total of 294 patients suspected of having coronary artery diseases underwent coronary computed tomographic angiography (CCTA) and SubCCTA. Coronary stenoses were blindly evaluated by two experienced radiologists, which were compared with invasive coronary angiography (ICA). Multiple statistical indexes were adopted to analyze the value of SubCCTA for the diagnosis of calcium stenoses.

Results

The diagnosable rate of SubCCTA was 67.2% (n=197), and the non-diagnosable rate was 32.8% (n=97). Using SubCCTA, the false positive rate decreased from 56.5% to 17.4%, and the corresponding diagnostic accuracy was increased from 83.6% to 92.9%. Univariate logistic regression analysis showed that height (OR=1.029, 95% CI=1.001–1.058), weight (OR=1.025, 95% CI=1.004–1.046), left ventricular size (OR=1.018, 95% CI=1.007–1.030), cardiothoracic ratio (OR=39.917, 95% CI=1.244–1281.098), the average heart rate (OR=0.866, 95% CI=0.836–0.896) and heart rate range (OR=0.882, 95% CI=0.853–0.912) might be the factors influencing SubCCTA.

Conclusion

This study suggested that SubCCTA could help improve diagnostic accuracy in the presence of calcium plaques. Moreover, several factors were discovered for the first time to possibly influence SubCCTA, which will be helpful in improving the subtracted image quality.

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Author notes

  1. These authors contribute equally to this work.

Authors and Affiliations

  1. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Chao Huang, Wei-jia Wan, Yu-huan Yao, Li-ming Xia & Wen-hua Huang

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  1. Chao Huang
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  2. Wei-jia Wan
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  3. Yu-huan Yao
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  4. Li-ming Xia
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  5. Wen-hua Huang
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Corresponding author

Correspondence to Wen-hua Huang.

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All authors declare no conflict of interests.

Additional information

This study was supported by Hubei Health Committee of China (No. WJ2019M119).

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Huang, C., Wan, Wj., Yao, Yh. et al. Feasibility of Subtraction Coronary Computed Tomographic Angiography and Influencing Factor Analysis: a Retrospective Study. CURR MED SCI 41, 821–826 (2021). https://doi.org/10.1007/s11596-021-2413-3

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  • DOI: https://doi.org/10.1007/s11596-021-2413-3

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