Summary
We previously reported that the increased expression of Dickkopf-related protein 1 (DKK1) is positively related to vascular endothelial growth factor in the synovial fluid from patients with temporomandibular joint disorders (TMDs). DKK1 is involved in angiogenic activities in the TMD synovium in vitro, but the expression of DKK1 after treatment of TMD-osteoarthritis (TMD-OA) with hyaluronic acid (HA) remains unknown. In this study, we assessed the expression of DKK1 in the synovial fluid of TMD-OA patients before and after treatment with HA via enzyme-linked immunosorbent assay. We also investigated the role of DKK1 in TMD-OA via immunohistochemical staining. The relationship between the expression of DKK1 and the clinicopathological characteristics was determined by Pearson analysis. The results showed that the expression of DKK1 was significantly decreased after treatment with HA. Correlation analyses indicated that the expression of DKK1 in the TMD-OA samples was closely correlated with mouth opening and pain. These findings suggest that DKK1 could play an important role in the pathogenesis and treatment of TMD. Reduction of the pain by HA treatment may be correlated with the decreased expression of DKK1.
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References
Scrivani SJ, Keith DA, Kaban LB. Temporomandibular disorders, N Engl J Med, 2008,359(25):2693–2705
Hampton T. Improvements needed in management of temporomandibular joint disorders. JAMA, 2008,299(10): 1119–1121
Donahue RP, Hu JC, Athanasiou KA. Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc. Trends Mol Med, 2019, 25(3):241–256
Sharma S, Wactawski-Wende J, LaMonte MJ, et al. Incident injury is strongly associated with subsequent incident temporomandibular disorder: results from the OPPERA study. Pain, 2019, 160(7):1551–1561
Theologis T, Efstathopoulos N, Nikolaou V, et al. Association between serum and synovial fluid Dickkopf-1 levels with radiographic severity in primary knee osteoarthritis patients. Clin Rheumatol, 2017, 36(8):1865–1872
Ferreira N, Masterson D, Lopes de Lima R, et al. Efficacy of viscosupplementation with hyaluronic acid in temporomandibular disorders: A systematic review. J Craniomaxillofac Surg, 2018, 46(11):1943–1952
Goiato MC, da Silva EV, de Medeiros RA, et al. Are intra-articular injections of hyaluronic acid effective for the treatment of temporomandibular disorders? A systematic review. Int J Oral Maxillofac Surg, 2016, 45(12):1531–1537
Liang L, Tu Y, Lu J, et al. Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/beta-catenin signaling pathway. J Cell Sci, 2019, 132 (10):doi: https://doi.org/10.1242/jcs.228478
Huang X, Post JN, Zhong L, et al. Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis. Osteoarthritis Cartilage, 2018, 26(6):834–843
Jiang SJ, Li W, Li YJ, et al. Dickkopfrelated protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders. Mol Med Rep, 2015, 12(4):4959–4966
Li W, Long X, Jiang S, et al. Histamine and substance P in synovial fluid of patients with temporomandibular disorders. J Oral Rehabil, 2015, 42(5):363–369
Sayour EJ, McLendon P, McLendon R, et al. Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma. Cancer Immunol Immunother, 2015, 64(4):419–427
Dong Y, Wu G, Zhu T, et al. VEGF promotes cartilage angiogenesis by phospho-ERK1/2 activation of Dll4 signaling in temporomandibular joint osteoarthritis caused by chronic sleep disturbance in Wistar rats. Oncotarget, 2017, 8(11):17849–17861
Liu J, Dai J, Wang Y, et al. Significance of new blood vessels in the pathogenesis of temporomandibular joint osteoarthritis. Exp Ther Med, 2017, 13(5):2325–2331
Xu L, Guo H, Li C, et al. A time-dependent degeneration manner of condyle in rat CFA-induced inflamed TMJ. Am J Transl Res, 2016, 8(2):556–567
Li L, Wang L, Sun Y, et al. Establishment and histological evaluation of a goat traumatic temporomandibular joint model. J Oral Maxillofac Surg, 2015, 73(5):943–950
Cevidanes LH, Walker D, Schilling J, et al. 3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease. Osteoarthritis Cartilage, 2014, 22(10):1657–1667
Zhang Y, Shao S, Zhang J, et al. Temporal summation and motor function modulation during repeated jaw movements in patients with temporomandibular disorder pain and healthy controls. Pain, 2017, 158(7):1272–1279
Ernberg M. The role of molecular pain biomarkers in temporomandibular joint internal derangement. J Oral Rehabil, 2017, 44(6):481–491
Macedo CG, Jain AK, Franz-Montan M, et al. Microneedles enhance topical delivery of 15-deoxy-Delta(12,14)-prostaglandin J2 and reduce nociception in temporomandibular joint of rats. J Control Release, 2017, 265:22–29
Zotti F, Albanese M, Rodella LF, et al. Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review. Int J Mol Sci, 2019, 20(2):277
Li H, Chen Y, Chen S. Enhancement of rotator cuff tendon-bone healing using bone marrow-stimulating technique along with hyaluronic acid. J Orthop Translat, 2019, 17:96–102
Puviani M, Campione E, Offidani AM, et al. Effects of a cream containing 5% hyaluronic acid mixed with a bacterial-wall-derived glycoprotein, glycyrretinic acid, piroctone olamine and climbazole on signs, symptoms and skin bacterial microbiota in subjects with seborrheic dermatitis of the face. Clin Cosmet Investig Dermatol, 2019, 12:285–293
Gokce Kutuk S, Gokce G, Arslan M, et al. Clinical and Radiological Comparison of Effects of Platelet-Rich Plasma, Hyaluronic Acid, and Corticosteroid Injections on Temporomandibular Joint Osteoarthritis. J Craniofac Surg, 2019, 30(4):1144–1148
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This study was supported by the Project of Wuhan University for Young Teachers (No. 2042018kf0145).
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Jiang, Sj., Jin, Zz. & Peng, Yj. Expression of Dickkopf-related Protein 1 in Patients with Temporomandibular Osteoarthritis after Treatment with Hyaluronic Acid. CURR MED SCI 40, 574–579 (2020). https://doi.org/10.1007/s11596-020-2215-z
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DOI: https://doi.org/10.1007/s11596-020-2215-z