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HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma

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Abstract

Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A*02-B*46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS (P=0.032, 0.040, and 0.013, respectively). We found that the HLA-A*02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC.

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Authors and Affiliations

  1. Department of Head and Neck Radiation Oncology, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, 830011, China

    Ruo-zheng Wang  (王若峥), Dian-gang Zhang  (张典刚), Ran Wu  (吴 冉), Yun-hui Hu  (胡云辉), Cheng Chang  (常 诚), Tao Dong  (董 涛) & Xi-yan Wang  (王喜艳)

  2. Department of Oncology, Bazhou People’s Hospital of Mongolian Autonomous Prefecture, Kuerle, 841000, China

    Ran Wu  (吴 冉)

  3. MRC Human Immunology Unit, Radcliffe Department of Medicine, Oxford University, Oxford, OX3 9DS, UK

    Yan-chun Peng  (彭艳春) & Tao Dong  (董 涛)

  4. Nuffield Department of Medicine, Oxford University, Oxford, OX3 9DU, UK

    Tao Dong  (董 涛)

Authors
  1. Ruo-zheng Wang  (王若峥)
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  2. Dian-gang Zhang  (张典刚)
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  3. Ran Wu  (吴 冉)
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  4. Yun-hui Hu  (胡云辉)
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  5. Yan-chun Peng  (彭艳春)
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  6. Cheng Chang  (常 诚)
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  7. Tao Dong  (董 涛)
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  8. Xi-yan Wang  (王喜艳)
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Corresponding author

Correspondence to Tao Dong  (董 涛).

Additional information

This project was supported by grants from the Chinese International Cooperation Project (No. 2012DFA31560), Key Laboratory Projects of Xinjiang Uygur Autonomous Region (No. 2015KL021), and the Achievement Promotion Projects of the Autonomous Region (No. 201554142).

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Wang, Rz., Zhang, Dg., Wu, R. et al. HLA-A*02-B*46 haplotype: an adverse prognostic factor in Han patients with nasopharyngeal carcinoma. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 700–704 (2016). https://doi.org/10.1007/s11596-016-1647-y

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  • DOI: https://doi.org/10.1007/s11596-016-1647-y

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