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Comparative analysis of general characteristics of ischemic stroke of BAD and non-BAD CISS subtypes

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Abstract

Based on the recently proposed Chinese ischemic stroke subclassification (CISS) system, intracranial branch atheromatous disease (BAD) is divided into large artery atherosclerosis (LAA) and penetrating artery disease (PAD). In the current retrospective analysis, we compared the general characteristics of BAD-LAA with BAD-PAD, BAD-LAA with non-BAD-LAA and BAD-PAD with non-BAD-PAD. The study included a total of 80 cases, including 45 cases of BAD and 35 cases of non-BAD. Subjects were classified using CISS system: BAD-LAA, BAD-PAD, non-BAD-LAA and non-BAD-PAD. In addition to analysis of general characteristics, the correlation between the factors and the two subtypes of BAD was evaluated. The number of cases included in the analysis was: 32 cases of BAD-LAA, 13 cases of BAD-PAD, 21 cases of non-BAD-LAA, and 14 cases of non-BAD-PAD. Diabetes mellitus affected more non-BAD-LAA patients than BAD-LAA patients (P=0.035). In comparison with non-BAD-PAD, patients with BAD-PAD were younger (P=0.040), had higher initial NIHSS score (P<0.001) and morbidity of ischemic heart disease (P=0.033). Within patients with BAD, the PAD subtype was associated with smoking (OR=0.043; P=0.011), higher low-density lipoprotein (OR=5.339; P=0.029), ischemic heart disease (OR=9.383; P=0.047) and diabetes mellitus (OR=12.59; P=0.020). It was concluded that large artery atherosclerosis was the primary mechanism of BAD. The general characteristics showed no significant differences between the CISS subtypes of LAA and PAD within BAD, as well as between the BAD and non-BAD within LAA subtype. Several differences between PAD subtypes of BAD and non-BAD were revealed.

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Authors and Affiliations

  1. Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Bin Mei  (梅 斌), Guang-zhi Liu  (刘广志), Yu-min Liu  (刘煜敏) & Jun-jian Zhang  (章军建)

  2. Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Yang Yang  (杨 阳) & Jiang-hui Cao  (曹江慧)

Authors
  1. Bin Mei  (梅 斌)
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  2. Guang-zhi Liu  (刘广志)
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  3. Yang Yang  (杨 阳)
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  4. Yu-min Liu  (刘煜敏)
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  5. Jiang-hui Cao  (曹江慧)
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  6. Jun-jian Zhang  (章军建)
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Correspondence to Jun-jian Zhang  (章军建).

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The authors contributed equally to this work.

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Mei, B., Liu, Gz., Yang, Y. et al. Comparative analysis of general characteristics of ischemic stroke of BAD and non-BAD CISS subtypes. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 35, 885–890 (2015). https://doi.org/10.1007/s11596-015-1523-1

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  • DOI: https://doi.org/10.1007/s11596-015-1523-1

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