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Relationship between acquired deficiency of vitamin K-dependent clotting factors and hemorrhage

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Summary

This study examined the changes of activities of vitamin K-dependent clotting factors (VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage. Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed. Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects. The results showed that the average activities of VKDCFs were decreased in the patients in comparison to the control subjects and significantly increased after treatment of these patients with vitamin K and blood products. Multivariate regression analysis indicated that decreased activity of VKDCF was not an independent risk factor for bleeding disorders owing to deficiency or metabolic disturbance of vitamin K. It was concluded that acquired deficiency of VKDCF occurs under a variety of pathologic conditions and is closely associated with hemorrhagic events. Administration of vitamin K and transfusion of blood products containing high concentrations of VKDCFs helps alleviate the hemorrhagic diseases.

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Authors and Affiliations

  1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Rui Yang  (杨 锐), Xiaoping Zhang  (张小平), Wenning Wei  (魏文宁), Mei Hong  (洪 梅), Yan Yang  (杨 焰) & Yu Hu  (胡 豫)

  2. Key Laboratory of Biological Targeted Therapy of Hubei Province, Wuhan, 430022, China

    Rui Yang  (杨 锐), Xiaoping Zhang  (张小平), Wenning Wei  (魏文宁), Mei Hong  (洪 梅), Yan Yang  (杨 焰) & Yu Hu  (胡 豫)

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  1. Rui Yang  (杨 锐)
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  2. Xiaoping Zhang  (张小平)
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  3. Wenning Wei  (魏文宁)
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  4. Mei Hong  (洪 梅)
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  5. Yan Yang  (杨 焰)
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  6. Yu Hu  (胡 豫)
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Corresponding author

Correspondence to Yu Hu  (胡 豫).

Additional information

These authors contributed equally to this work.

This project was supported by grants from the Ministry of Health of China (No.[2007]353), the National Natural Sciences Foundation of China (N0. 30700332), the National Outstanding Youth Foundation (No.30825018), and the National Basic Research Program (973 Program, No.2007CB935803).

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Yang, R., Zhang, X., Wei, W. et al. Relationship between acquired deficiency of vitamin K-dependent clotting factors and hemorrhage. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 30, 312–317 (2010). https://doi.org/10.1007/s11596-010-0348-1

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  • DOI: https://doi.org/10.1007/s11596-010-0348-1

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