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Endogenous ouabain in hypertensive disorder complicating pregnancy

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Summary

Expression of endogenous ouabain in placenta and the concentrations of serum ET-1 and NO were examined in 30 patients with hypertensive disorder complicating pregnancy (HDCP) and 30 healthy pregnant women to investigate the effect of endogenous ouabain on HDCP. Compared with the healthy pregnant group, the expression of endogenous ouabain dramatically increased in the HDCP groups (P<0.01). There was a significantly positive correlation between the expression of endogenous ouabain with ET-1 (r=0.5567, P<0.01), while the correlation of endogenous ouabain and NO was significantly negative (r=−0.6895, P<0.01). As expected, the correlation between ET-1 and NO was negative (r=−0.7796, P<0.01). ET-1 concentrations of maternal and cord sera in HDCP groups were significantly higher in comparison with healthy pregnant group (P<0.01). On the contrast, NO concentrations were much lower in the maternal and cord sera of HDCP groups as compared with healthy pregnant group (P<0.01). Our data suggest that endogenous ouabain is directly involved in the nosogenesis of HDCP, with accompanying decreased NO and the elevated of ET-1.

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References

  1. Le J. Obstetrics and Gynecology. 6th edition. Beijing: People’s Medical Publishing House (Chinese), 2006. 96–104

    Google Scholar 

  2. Takahashi H, Matsuzawa M, Okabayashi H et al. Evidence for a digitalis-like substance in the hypothalamopituitary axis in rats: implications in the central cardiovascular regulation associated with an excess intake of sodium. Jpn Circ J, 1987,51(10):1199–2071

    CAS  PubMed  Google Scholar 

  3. Takahashi H, Matsusawa M, Ikegaki I et al. Digitalis-like substance is produced in the hypothalamus but not in the adrenal gland in rats. J Hypertens, 1988,6(4):S345–S347

    CAS  Google Scholar 

  4. Fedorova O V, Agalakova N I, Talan M I et al. Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signaling in NaCl-loaded Dahl-S rats. J Hypertens, 2005, 23(8):1515–1523

    Article  CAS  PubMed  Google Scholar 

  5. Ceolotto G, Sartori M, Papparella I et al. Different effect of ouabain on endothelin-1-induced extracellular signal-regulated kinase stimulation in rat heart and tail artery. J Cardiovasc Pharmacol, 2003,41(4):553–561

    Article  CAS  PubMed  Google Scholar 

  6. Xavier F E, Yogi A, Callera G E et al. Contribution of the endothelin and renin-angiotensin systems to the vascular changes in rats chronically treated with ouabain. Br J Pharmacol, 2004,143(6):794–802

    Article  CAS  PubMed  Google Scholar 

  7. Karagiannis J, Rand M, Li C G. Role of gap junctions in endothelium-derived hyperpolarizing factor-mediated vasodilatation in rat renal artery. Acta Pharmacol Sin, 2004,25(8):1031–1037

    CAS  PubMed  Google Scholar 

  8. Fedorova O V, Agalakova N I, Talan M I et al. Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signaling in NaCl-loaded Dahl-S rats. J Hypertens, 2005,23(8):1515–1523

    Article  CAS  PubMed  Google Scholar 

  9. Ge H, Lu Z R, Yu W et al. Approach the effect of endogenous ouabain in the pathogenesis of hypertension. Chin J Cardio (Chinese), 1999,27(4):271–272

    Google Scholar 

  10. Yanagisawa M, Kurihara H, Kimura S et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 1988,332(6163):411–415

    Article  CAS  PubMed  Google Scholar 

  11. Li Yi, Jin T, Zhang Y et al. Effects of Ratio of NitrIC Oxide / Endothelin on Pathogenesis of Pregnancy Induced Hypertension. Tianjin Med J (Chinese), 2003,31(11):698–700

    CAS  Google Scholar 

  12. Saunders R, Scheiner-Bobis G. Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump. Eur J Biochem, 2004271(5):1054–1062

    Article  CAS  PubMed  Google Scholar 

  13. Di Filippo C, Filippelli A, Rinaldi B et al. Chronic peripheral ouabain treatment affects the brain endothelin system of rats. J Hypertens, 2003,21(4):747–753

    Article  PubMed  Google Scholar 

  14. Xavier F E, Rossoni L V, Alonso M J et al. Ouabain-induced hypertension alters the participation of endothelial factors in alpha-adrenergic responses differently in rat resistance and conductance mesenteric arteries. Br J Pharmacol, 2004,143(1):215–225

    Article  CAS  PubMed  Google Scholar 

  15. Zhang H W, Fan H X, Ren H X et al. Research method of production ouabain antibody. J Xi’an Med Univer (Chinese), 2001, 22(1):72–74

    Google Scholar 

  16. Tang M Y. Placenta Pathology. Primary edition. Beijing Medical Publishing House (Chinese), 1987.6–10

  17. Ren Y P, Lu Z R. Effect of Ouabain on human vascular endothelial cells. Chin J Hypertension (Chinese), 2003,11(6):599–603

    Google Scholar 

  18. Jiang X, Guo N, Lv Z R et al. Effects of ouabain on endothelin system in rat heart. J Xi’an Jiaotong Univer (Med Sci) (Chinese), 2005,26(6):519–522

    CAS  Google Scholar 

  19. Wang C H, Zhen X R, Fang J Z et al. The Influence Factors in Sera of Patients with Pregnancy-induced Hypertension on the Synthesis of Nitric Oxide and Endothelin-1 of Endothelial Cells. Bull Hunan Med Univer (Chinese), 2000,25(6):595–596

    CAS  Google Scholar 

  20. Goto A, Yamada K. Putative roles of ouabain-like compound in hypertension: revisited. Hypertens Res, 2000,9(23):S7–S13

    Article  Google Scholar 

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Authors and Affiliations

  1. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Wu Li  (吴 黎), Xiong Chengliang  (熊承良) & Su Ping  (苏 萍)

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  1. Wu Li  (吴 黎)
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  2. Xiong Chengliang  (熊承良)
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  3. Su Ping  (苏 萍)
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Additional information

This project was supported by grants from the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (NO: 200414519001).

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Wu, L., Xiong, C. & Su, P. Endogenous ouabain in hypertensive disorder complicating pregnancy. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 27, 717–720 (2007). https://doi.org/10.1007/s11596-007-0626-8

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  • DOI: https://doi.org/10.1007/s11596-007-0626-8

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