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A novel integration of spectral-domain optical-coherence-tomography and laser-ablation system for precision treatment

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Complete resection of diseased lesions reduces the recurrence of cancer, making it critical for surgical treatment. However, precisely resecting residual tumors is a challenge during operation. A novel integrated spectral-domain optical-coherence-tomography (SD-OCT) and laser-ablation therapy system for soft-biological-tissue resection is proposed. This is a prototype optical integrated diagnosis and therapeutic system as well as an optical theranostics system.

Methods

We develop an optical theranostics system, which integrates SD-OCT, a laser-ablation unit, and an automatic scanning platform. The SD-OCT image of biological tissue provides an intuitive and clear view for intraoperative diagnosis and monitoring in real time. The effect of laser ablation is analyzed using a quantitative mathematical model. The automatic endoscopic scanning platform combines an endoscopic probe and an SD-OCT sample arm to provide optical theranostic scanning motion. An optical fiber and a charge-coupled device camera are integrated into the endoscopic probe, allowing detection and coupling of the OCT-aiming beam and laser spots.

Results

The integrated diagnostic and therapeutic system combines SD-OCT imaging and laser-ablation modules with an automatic scanning platform. OCT imaging, laser-ablation treatment, and the integration and control of diagnostic and therapeutic procedures were evaluated by performing phantom experiments. Furthermore, SD-OCT-guided laser ablation provided precision laser ablation and resection for the malignant lesions in soft-biological-tissue-lesion surgery. The results demonstrated that the appropriate laser-radiation power and duration time were 10 W and 10 s, respectively. In the laser-ablation evaluation experiment, the error reached approximately 0.1 mm. Another validation experiment was performed to obtain OCT images of the pre- and post-ablated craters of ex vivo porcine brainstem.

Conclusion

We propose an optical integrated diagnosis and therapeutic system. The primary experimental results show the high efficiency and feasibility of our theranostics system, which is promising for realizing accurate resection of tumors in vivo and in situ in the future.

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Acknowledgements

This work was partially supported by National Natural Science Foundation of China (Grant Nos. 81427803, 61361160417, 81271735), Beijing Municipal Science and Technology Commission (Z151100003915079), and Beijing National Science Foundation (7172122). The brainstem and brain tumor samples and MRI data are provided by Dr. Liwei Zhang and Dr. Changcun Pan in Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Another home-built OCT module, which is used into the section “3.4 Validation experiment of OCT images of pre- and post-ablated craters with samples,” is provided by Mr. Site Luo in Department of Electronic Engineering, Tsinghua University, Beijing, China.

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Authors and Affiliations

  1. Department of Biomedical Engineering, School of Medicine, Tsinghua University, Qinghuayuan Street, Haidian District, 100084, Beijing, China

    Yingwei Fan, Boyu Zhang, Wei Chang, Xinran Zhang & Hongen Liao

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  1. Yingwei Fan
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  2. Boyu Zhang
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  3. Wei Chang
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  4. Xinran Zhang
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  5. Hongen Liao
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Correspondence to Hongen Liao.

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The authors declare no competing financial interests.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Fan, Y., Zhang, B., Chang, W. et al. A novel integration of spectral-domain optical-coherence-tomography and laser-ablation system for precision treatment. Int J CARS 13, 411–423 (2018). https://doi.org/10.1007/s11548-017-1664-8

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  • DOI: https://doi.org/10.1007/s11548-017-1664-8

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