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Detection of Crohn’s disease with diffusion images versus contrast-enhanced images in pediatric using MR enterography with histopathological correlation

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Abstract

The purpose of this study was to determine whether MRE performed with diffusion-weighted imaging (DWI) sequences is comparable to contrast-enhanced MRE in the detection of active small-bowel inflammation in pediatric patients with Crohn’s disease (CD). We included in our study 68 patients with diagnosis of CD between April 2015 and June 2018 that underwent MRE examination. Examination protocol includes coronal and axial FISP, T2-w half-Fourier RARE and DWI sequences, a baseline coronal T1-w fat-saturated ultrafast (GRE) sequence followed by contrast 3D T1-w GRE. All images were assessed by two radiologists who graded each of bowel segments for the presence of inflammation on a four-point confidence scale on the basis of wall thickening and wall signal on DWI and ADC maps and comparing their results with post-contrast images. When considering all bowel segments, we found 41 true positive and 25 true negative on DWI. One false positive case corresponded to the absence of inflammatory histopathology changes at the level of the terminal ileum in a 15-year-old male, and one false negative case was in a 10-year-old female with only jejunal lesion. The corresponding sensitivity, specificity, PPV, NPV and accuracy were 97.6% (95% CI 67.7–99.7), 96.1% (95% CI 66.7–98.5), 97.6% (95% CI 70.8–98.4), 96.1% (95% CI 64.2–90.6) and 97% (95% CI 84.2–97.5), respectively. Analyzing the gadolinium-enhanced set, 35 true positive and 25 true negative results were found. One false positive case was found, and it was the same as with DWI. The corresponding sensitivity, specificity, PPV, NPV and accuracy were 83.3% (95% CI 65.9–86.7), 96.1% (95% CI 68.7–88.9), 97.2% (95% CI 84.3–98.7), 78.1% (95% CI 27.9–72.1) and 88.2% (95% CI 41.2–85.6), respectively. Sensitivity for the detection of active IBD lesion was significantly better with DWI than with CE-T1-w imaging (p = 0.002), whereas the specificity was similar (p = 0.743). Our study has shown that DWI sequences have a high accuracy in detecting the bowel segment affected by CD. These results emphasize the utility to include the DWI/ADC in standard MR enterography protocols and suggest that DWI could replace T1-weighted post-contrast sequences.

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Authors and Affiliations

  1. Radiology Department, Umberto I Hospital, Sapienza University, Viale del Policlinico 155, 00161, Rome, Italy

    Gabriele Masselli, Chiara De Vincentiis, Marianna Guida, Roberta Cao & Gaia Cartocci

  2. Pediatric Department, Umberto I Hospital, Sapienza University, Viale del Policlinico 155, 00161, Rome, Italy

    Marina Aloi

  3. Radiology Department, Careggi University Hospital, University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy

    Vittorio Miele

  4. Radiology Department, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138, Naples, Italy

    Roberto Grassi

Authors
  1. Gabriele Masselli
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  2. Chiara De Vincentiis
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  3. Marina Aloi
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  4. Marianna Guida
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Correspondence to Gabriele Masselli.

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The present study was conducted in accordance with the institutional ethical committee of Sapienza University of Rome.

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Parent or guardian informed consent was obtained at the time of study enrollment.

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Masselli, G., De Vincentiis, C., Aloi, M. et al. Detection of Crohn’s disease with diffusion images versus contrast-enhanced images in pediatric using MR enterography with histopathological correlation. Radiol med 124, 1306–1314 (2019). https://doi.org/10.1007/s11547-019-01067-z

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  • DOI: https://doi.org/10.1007/s11547-019-01067-z

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