Abstract
Purpose
This study aimed to evaluate the prevalence of chronic cerebrospinal venous insufficiency (CCSVI) in patients with multiple sclerosis (MS).
Material and methods
From November 2009 to February 2010, 74 participants (40 MS patients and 34 healthy controls) were enrolled in a randomised singleblind prospective study. All participants underwent ultrasonography (US) to detect signs of CCSVI.
Results
CCSVI was detected in 55% of patients in the MS group and 35% in the control group; the difference was not statistically significant (p=0.089).
Conclusions
In our experience, a slight difference exists in the prevalence of CCSVI between MS and healthy controls, but it is not as yet clear which parameters may be most significant. This preliminary study failed to show a statistically significant difference in the prevalence of CCSVI among patients affected by MS. It did, however, reveal a tendency that requires a larger number of patients to achieve statistically significant results.
Riassunto
Obiettivo
Scopo del presente lavoro è stato valutare la prevalenza dell’insufficienza venosa cerebrospinale cronica (CCSVI) in soggetti affetti da sclerosi multipla (SM).
Materiali e metodi
Da novembre 2009 a febbraio 2010 74 soggetti (40 affetti da SM e 34 casi controllo) sono stati arruolati in uno studio prospettico randomizzato a singolo cieco. Tutti i soggetti sono stati sottoposti ad ecografia per la ricerca di segni di CCSVI.
Risultati
Lo studio ha evidenziato una percentuale di pazienti affetti da CCSVI del 55%, nel gruppo dei pazienti affetti da SM, e del 35% nel gruppo controllo con una differenza statisticamente non significativa (p=0,089).
Conclusioni
Esiste una lieve differenza di prevalenza di CCSVI tra i soggetti affetti da SM e quelli sani nella nostra valutazione, ma ad oggi non sono stati individuati quali tra i numerosi parametri siano i più significativi. Da questo studio preliminare, non è emersa una differenza statisticamente significativa nella prevalenza della CCSVI in pazienti affetti da SM. Tuttavia i dati indicano una tendenza che richiede un più alto numero di pazienti per ottenere risultati definitivi.
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References/Bibliografia
Noseworthy JH, Luchinetti C, Rodriguez M, Weinshenker BG (2000) Multiple sclerosis. N Engl J Med 343:938–952
Barnett MH, Sutton I (2006) The pathology of multiple sclerosis: a paradigm shift. Curr Opin Neurol 19:242–247
Lassmann H (2005) Multiple sclerosis pathology: evolution of pathogenetic concepts. Brain Pathol 15:217–222
Zamboni P, Menegatti E, Galeotti R et al (2009) The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J Neurol Sci 282:21–27
Zamboni P, Galeotti R, Menegatti E et al (2009) A prospective openlabel study of endovascular treatment of chronic cerebrospinal venous insufficiency. J Vasc Surg 50:1348–1358
Doepp F, Paul F, Valdueza JM et al (2010) No cerebrocervical venous congestion in patients with multiple sclerosis. Ann Neurol 68:173–183
Zivadinov R, Schirda C, Dwyer MG et al (2010) Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int Angiol 29:158–175
Passariello R, Cozzi F, Casalena G et al (1979) Angiographic diagnosis of jugular venous system dilatation in children. A report of five cases. Pediatr Radiol 8:247–250
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Floris, R., Centonze, D., Fabiano, S. et al. Prevalence study of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: preliminary data. Radiol med 117, 855–864 (2012). https://doi.org/10.1007/s11547-011-0767-5
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DOI: https://doi.org/10.1007/s11547-011-0767-5