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Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta

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Abstract

Lower limb deformation in children with osteogenesis imperfecta (OI) impairs ambulation and may lead to fracture. Corrective surgery is based on empirical assessment criteria. The objective was to develop a reconstruction method of the tibia for OI patients that could be used as input of a comprehensive finite element model to assess fracture risks. Data were obtained from three children with OI and tibia deformities. Four pQCT scans were registered to biplanar radiographs, and a template mesh was deformed to fit the bone outline. Cortical bone thickness was computed. Sensitivity of the model to missing slices of pQCT was assessed by calculating maximal von Mises stress for a vertical hopping load case. Sensitivity of the model to ±5 % of cortical thickness measurements was assessed by calculating loads at fracture. Difference between the mesh contour and bone outline on the radiographs was below 1 mm. Removal of one pQCT slice increased maximal von Mises stress by up to 10 %. Simulated ±5 % variation of cortical bone thickness leads to variations of up to 4.1 % on predicted fracture loads. Using clinically available tibia imaging from children with OI, the developed reconstruction method allowed the building of patient-specific finite element models.

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Funding

Réseau de recherche en santé buccodentaire et osseuse (RSBO), Shriners of North America and Canada Research Chair in Orthopedic Engineering.

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Authors and Affiliations

  1. Canada Research Chair in Orthopedic Engineering, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada

    Christiane Caouette, Nicole Ikin & Carl-Éric Aubin

  2. Sainte-Justine University Hospital Center, Montréal, QC, Canada

    Christiane Caouette, Isabelle Villemure, Frank Rauch & Carl-Éric Aubin

  3. IFSTTAR, Aix-Marseille University, Marseille, France

    Pierre-Jean Arnoux

  4. Shriners Hospital for Children, Montréal, QC, Canada

    Frank Rauch

  5. McGill University, Montreal, QC, Canada

    Frank Rauch

  6. iLab-Spine (International Laboratory - Spine Imaging and Biomechanics), Montreal, QC, Canada

    Christiane Caouette, Isabelle Villemure & Carl-Éric Aubin

  7. iLab-Spine (International Laboratory - Spine Imaging and Biomechanics), Marseille, France

    Pierre-Jean Arnoux

  8. Canada Research Chair in Mechanobiology of the Pediatric Musculoskeletal System, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada

    Christiane Caouette & Isabelle Villemure

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  1. Christiane Caouette
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  2. Nicole Ikin
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  3. Isabelle Villemure
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  4. Pierre-Jean Arnoux
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  5. Frank Rauch
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  6. Carl-Éric Aubin
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Correspondence to Carl-Éric Aubin.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Caouette, C., Ikin, N., Villemure, I. et al. Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta. Med Biol Eng Comput 55, 549–560 (2017). https://doi.org/10.1007/s11517-016-1526-5

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  • DOI: https://doi.org/10.1007/s11517-016-1526-5

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