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Improved robust T-wave alternans detectors

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Abstract

New statistical and spectral detectors, the modified matched pairs t test, the extended spectral method and the modified spectral method, were proposed for T-wave alternans (TWA) detection gaining robustness according to trend and single-frequency interferences. They were compared to classic detectors such as matched pairs t test, unpaired t test, spectral method, generalized likelihood ratio test and estimated TWA amplitude within a simulation framework and applied to real data. The optimal detection threshold was selected by using a full Monte-Carlo simulation where signals, with and without alternans episodes, were corrupted by Gaussian noise with different power and single-frequency interferences with different tones. All the combinations of noise and frequency were selected and repeated 500 times in order to compute probability of detection (\(P_{\mathrm{d}}\)) and the false alarm probability (\(P_{\mathrm{fa}}\)), providing ROC curves. The study group consisted of 50 patients with implantable cardioverter-defibrillator (age: \(55.3 \pm 16.4\); LVEF: \(42.8 \pm 15.5\)), who were paced (ventricular pacing) at 100 bpm. Two-minute recordings were analyzed. The XYZ orthogonal lead system was used. The best performance was reached by using the modified matched pairs t test (in comparison with the spectral method and other reference methods).

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Acknowledgments

This work was partially supported by the research project DEC-2011/01/B/ST7/06801 of the Polish National Science Centre.

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Authors and Affiliations

  1. Laboratoire I3S UNS-CNRS UMR7172, Université de Nice-Sophia Antipolis, 2000 route des lucioles Les Algorithmes - bt. Euclide B, CS 40121, 06903, Sophia Antipolis Cedex, France

    O. Meste

  2. Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Ks Trojdena 4 St., 02-109, Warsaw, Poland

    D. Janusek, M. Kania & R. Maniewski

  3. Warsaw Education Center CVG Medtronic Poland, Warsaw, Poland

    S. Karczmarewicz

  4. Cardiac Arrhythmias Department, National Institute of Cardiology, Warsaw, Poland

    A. Przybylski & A. Maciag

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  1. O. Meste
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  2. D. Janusek
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  3. S. Karczmarewicz
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  4. A. Przybylski
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  5. M. Kania
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  6. A. Maciag
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  7. R. Maniewski
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Correspondence to O. Meste.

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Meste, O., Janusek, D., Karczmarewicz, S. et al. Improved robust T-wave alternans detectors. Med Biol Eng Comput 53, 361–370 (2015). https://doi.org/10.1007/s11517-015-1243-5

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  • DOI: https://doi.org/10.1007/s11517-015-1243-5

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