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Significance of the potential role of pharmacological MRI (phMRI) in diagnosis of Parkinson’s disease

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Frontiers in Biology

Abstract

The initial diagnosis of Parkinson’s disease (PD) is currently based on a clinical assessment. Many patients who receive an initial diagnosis of PD have parkinsonian features related to other diseases such as essential tremor, vascular parkinsonism and atypical parkinsonian disorder. It has been challenging to differentiate PD from those disorders, especially in the early disease stages, due to an overlap of clinical signs and symptoms. Therefore, there is a great need for development of noninvasive, highly sensitive, and widely available imaging methods that can potentially be used to assistant physicians to make more accurate diagnosis of the disease; and to longitudinally monitor treatment of PD. Recent advance of pharmacological MRI (phMRI) technology allows non-invasively mapping functional stages for nigrostriatal dopamine (DA) system. This article aims to review research findings primarily from our group in nonhuman primates modeling the neurodegenerative disease on the value of phMRI techniques in the diagnosis of PD.

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References

  • Andersen A H, Zhang Z, Barber T, Rayens W S, Zhang J, Grondin R, Hardy P, Gerhardt G A, Gash DM (2002). Functional MRI studies in awake rhesus monkeys: methodological and analytical strategies. J Neurosci Methods, 118(2): 141–152

    Article  PubMed  Google Scholar 

  • Arthurs O J, Boniface S (2002). How well do we understand the neural origins of the fMRI BOLD signal? Trends Neurosci, 25(1): 27–31

    Article  PubMed  CAS  Google Scholar 

  • Braak H, Del Tredici K (2008). Cortico-basal ganglia-cortical circuitry in Parkinson’s disease reconsidered. Exp Neurol, 212(1): 226–229

    Article  PubMed  Google Scholar 

  • Chen Q, Andersen A H, Zhang Z, Ovadia A, Gash D M, Avison M J (1996). Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI. Magn Reson Imaging, 14(5): 469–476

    Article  PubMed  CAS  Google Scholar 

  • Chin C L, Tovcimak A E, Hradil V P, Seifert T R, Hollingsworth P R, Chandran P, Zhu C Z, Gauvin D, Pai M, Wetter J, Hsieh G C, Honore P, Frost J M, Dart M J, Meyer M D, Yao B B, Cox B F, Fox G B (2008). Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI. Br J Pharmacol, 153(2): 367–379

    Article  PubMed  CAS  Google Scholar 

  • Ding F, Luan L, Ai Y, Walton A, Gerhardt G A, Gash D M, Grondin R, Zhang Z (2008). Development of a stable, early stage unilateral model of Parkinson’s disease in middle-aged rhesus monkeys. Exp Neurol, 212(2): 431–439

    Article  PubMed  Google Scholar 

  • Fearnley J M, Lees A J (1991). Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain, 114(5): 2283–2301

    Article  PubMed  Google Scholar 

  • Honey G, Bullmore E (2004). Human pharmacological MRI. Trends Pharmacol Sci, 25(7): 366–374

    Article  PubMed  CAS  Google Scholar 

  • Jenkins B G, Sanchez-Pernaute R, Brownell A L, Chen Y C, Isacson O (2004). Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. J Neurosci, 24(43): 9553–9560

    Article  PubMed  CAS  Google Scholar 

  • Langston J W, Ballard P A Jr (1983). Parkinson’s disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N Engl J Med, 309(5): 310–321

    PubMed  CAS  Google Scholar 

  • Nguyen T V, Brownell A L, Iris Chen Y C, Livni E, Coyle J T, Rosen B R, Cavagna F, Jenkins B G (2000). Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse, 36(1): 57–65

    Article  PubMed  CAS  Google Scholar 

  • Nicklas W J, Youngster S K, Kindt M V, Heikkila R E (1987). MPTP, MPP+ and mitochondrial function. Life Sci, 40(8): 721–729

    Article  PubMed  CAS  Google Scholar 

  • Pavese N, Brooks D J (2009). Imaging neurodegeneration in Parkinson’s disease. Biochim Biophys Acta, 1792(7): 722–729

    PubMed  CAS  Google Scholar 

  • Rasmussen I Jr (2010). Psychopharmacological MRI. Acta Neuropsychiatr, 22(1): 38–39

    Article  Google Scholar 

  • Richardson J R, Caudle WM, Guillot T S, Watson J L, Nakamaru-Ogiso E, Seo B B, Sherer T B, Greenamyre J T, Yagi T, Matsuno-Yagi A, Miller G W (2007). Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol Sci, 95(1): 196–204

    Article  PubMed  CAS  Google Scholar 

  • Thiel C M (2009). Neuropharmacological fMRI. Neuropharmakologisches fMRT, 40: 233–238

    Google Scholar 

  • Tracey I (2001). Prospects for human pharmacological functional magnetic resonance imaging (phMRI). J Clin Pharmacol, Suppl: 21S–28S

    PubMed  CAS  Google Scholar 

  • Wu Y, Le W, Jankovic J (2011). Preclinical biomarkers of Parkinson disease. Arch Neurol, 68(1): 22–30

    Article  PubMed  Google Scholar 

  • Zhang Z, Andersen A, Grondin R, Barber T, Avison R, Gerhardt G, Gash D (2001). Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. Neuroimage, 14(5): 1159–1167

    Article  PubMed  CAS  Google Scholar 

  • Zhang Z, Andersen A H, Ai Y, Loveland A, Hardy P A, Gerhardt G A, Gash D M (2006). Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. Neuroimage, 33: 636–643

    Article  PubMed  Google Scholar 

  • Zhang Z, Andersen A, Grondin R, Barber T, Avison R, Gerhardt G, Gash D (2001). Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. Neuroimage, 14(5): 1159–1167

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurobiology and Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, Beijing, 100053, China

    Feng Yue & Piu Chan

  2. Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY, 40536, USA

    Zhiming Zhang

Authors
  1. Feng Yue
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  2. Piu Chan
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  3. Zhiming Zhang
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Correspondence to Zhiming Zhang.

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Yue, F., Chan, P. & Zhang, Z. Significance of the potential role of pharmacological MRI (phMRI) in diagnosis of Parkinson’s disease. Front. Biol. 7, 307–312 (2012). https://doi.org/10.1007/s11515-012-1023-7

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  • DOI: https://doi.org/10.1007/s11515-012-1023-7

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