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Histiozytär nekrotisierende Lymphadenitis

Assoziation mit Diabetes mellitus Typ 1 und Autoimmunthyreopathie

Histiocytic necrotizing lymphadenitis

Association with type 1 diabetes mellitus and autoimmune thyroiditis

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Zusammenfassung

Die histiozytär nekrotisierende Lymphadenitis (Synonym: Kikuchi-Fujimoto-Erkrankung) ist eine seltene Form der Lymphadenitis, die sich charakteristischerweise mit zervikaler Lymphadenopathie und Fieber präsentiert. Ätiologie und Pathogenese der Erkrankung sind unbekannt, wobei eine Assoziation mit Autoimmunerkrankungen besteht. Ein Zusammenhang mit Infektionen wird diskutiert. Wir berichten über eine 23-jährige pakistanisch-stämmige Patientin mit vorbestehendem Diabetes mellitus Typ 1, euthyreoter Autoimmunthyreoiditis und einem (mutmaßlichen) Rezidiv ihrer Kikuchi-Fujimoto-Erkrankung im Kontext einer Infektion mit Achromobacter xylosoxidans.

Abstract

Histiocytic necrotizing lymphadenitis (synonym: Kikuchi-Fujimoto disease) is a rare form of lymphadenitis that characteristically presents with cervical lymphadenopathy and fever. The etiology and pathogenesis are unknown although there is an association with autoimmune diseases. A correlation with infections is discussed. This article presents the case of a 23-year-old woman of Pakistani origin with pre-existing type 1 diabetes mellitus, euthyroid autoimmune thyroiditis and (presumed) recurrent Kikuchi-Fujimoto disease in the context of an Achromobacter xylosoxidans infection.

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Authors and Affiliations

  1. Medizinische Klinik 1, Universitätsklinikum/Goethe-Universität, Theodor-Stern Kai 7, 60590, Frankfurt am Main, Deutschland

    A. Schappert, D. Bergis, S. Zeuzem & K. Badenhoop

  2. Zentrum der Dermatologie und Venerologie, Universitätsklinikum/Goethe-Universität, Frankfurt am Main, Deutschland

    R. Kaufmann

  3. Dr. Senckenbergisches Institut für Pathologie, Universitätsklinikum/Goethe-Universität, Frankfurt am Main, Deutschland

    S. Hartmann

  4. III. Medizinische Klinik, Sektion Rheumatologie & klinische Immunologie, Klinikum Augsburg, Augsburg, Deutschland

    M. Wahle

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  1. A. Schappert
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Correspondence to A. Schappert.

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Interessenkonflikt

A. Schappert, D. Bergis, R. Kaufmann, S. Hartmann, M. Wahle, S. Zeuzem und K. Badenhoop geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben.

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Informierte Einwilligung: Die Patientin stimmte der Veröffentlichung ihrer Fallgeschichte zu.

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Schappert, A., Bergis, D., Kaufmann, R. et al. Histiozytär nekrotisierende Lymphadenitis. Diabetologe 12, 352–357 (2016). https://doi.org/10.1007/s11428-016-0106-5

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  • DOI: https://doi.org/10.1007/s11428-016-0106-5

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