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Systemische Vitamin-D-Wirkung und Typ-2-Diabetes

Systemic vitamin D effect and type 2 diabetes

  • Leitthema
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Der Diabetologe Aims and scope

Zusammenfassung

Hintergrund

Diabetes mellitus Typ 2 (T2D) ist eine der wichtigsten Volkskrankheiten mit stetig steigender Patientenzahl. Studien zufolge steht der Vitamin-D-Mangel (VD-Mangel) mit verschiedenen Erkrankungen in Zusammenhang. Viele Patienten, insbesondere auch an T2D Erkrankte, weisen einen solchen auf. Als Indikator des VD-Status kann der 25-OH-Vitamin-D3-Serumspiegel herangezogen werden.

Fragestellung

Um eine ausgewogene Übersicht über die Zusammenhänge zwischen VD und T2D zu erstellen, wurden die neuesten Veröffentlichungen überprüft.

Ergebnisse

Ein niedriger VD-Status ist mit einer erhöhten Inzidenz des T2D und einem vermehrten Auftreten seiner mikro- und makrovaskulären Komplikationen assoziiert. In interventionellen Studien konnte durch eine VD-Supplementierung bei Patienten mit T2D die Insulinresistenz signifikant verringert werden. In anderen interventionellen Studien wurde hierdurch keine Verbesserung der Stoffwechseleinstellung erzielt.

Schlussfolgerung

Es besteht eine Korrelation zwischen dem VD-Status und T2D. Die VD-Gabe bei T2D zeigte in mehreren Studien signifikant positive Effekte auf die Stoffwechseleinstellung, in anderen Studien jedoch nicht. Aufgrund des unterschiedlichen Studiendesigns und der daher nur geringen Vergleichbarkeit sind weitere Untersuchungen erforderlich.

Abstract

Background

Type 2 diabetes (T2D) is one of the most important chronic diseases with continuously rising numbers of patients. Vitamin D (VD) has been found to be deficient in several diseases. The 25(OH)D3 serum level is commonly used as an indicator of the VD status.

Objectives

In order to obtain a balanced overview on associations between VD and T2D, recent publications were reviewed.

Results

Low VD status is associated with an increased incidence of T2D and its micro- and macrovascular complications. VD supplementation reduced insulin resistance in patients with T2D in some interventional studies; in other studies, no improvement was observed.

Conclusion

There is a correlation between VD status and T2D. In several studies VD supplementation in T2D showed significant, positive effects on metabolism, which was not confirmed in others. Due to the heterogeneous designs, these studies are hardly comparable; therefore, further controlled trials with well-defined endpoints are required.

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Authors and Affiliations

  1. Gemeinschaftspraxis Dres. med. T. und A. Stirn, U. Emmrich, Fachärzte für Allgemeinmedizin, Wiesbaden, Deutschland

    F. Bruns

  2. Med. Klinik 1, Zentrum der Inneren Medizin, Universitätskliniken Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland

    N. Nejatian

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Correspondence to N. Nejatian.

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Interessenkonflikt

F. Bruns und N. Nejatian geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Bruns, F., Nejatian, N. Systemische Vitamin-D-Wirkung und Typ-2-Diabetes. Diabetologe 12, 240–247 (2016). https://doi.org/10.1007/s11428-016-0097-2

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