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Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium

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  • SCLS-CBIS Joint Life Science Research Workshop
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Abstract

The Hedgehog (Hh) signaling is one of the essential signaling pathways during embryogenesis and in adults. Hh signal transduction relies on primary cilium, a specialized cell surface organelle viewed as the hub of cell signaling. Protein kinase A (PKA) has been recognized as a potent negative regulator of the Hh pathway, raising the question of how such a ubiquitous kinase specifically regulates one signaling pathway. We reviewed recent genetic, molecular and biochemical studies that have advanced our mechanistic understanding of PKA’s role in Hh signaling in vertebrates, focusing on the compartmentalized PKA at the centrosome and in the primary cilium. We outlined the recently developed genetic and optical tools that can be harvested to study PKA activities during the course of Hh signal transduction.

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Acknowledgements

This work was supported by the National Institutes of Health (CA235749). We apologize to the investigators whose work we were unable to cite owing to space constraints and the investigators working in the many important areas of Hh signaling we were unable to cover. We thank Dr. Aaron Gitler for comments on the manuscript.

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    Eva Cai, Jingyi Zhang & Xuecai Ge

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Cai, E., Zhang, J. & Ge, X. Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium. Sci. China Life Sci. 65, 500–514 (2022). https://doi.org/10.1007/s11427-021-1975-9

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