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Quantification of selected monohydroxy metabolites of polycyclic aromatic hydrocarbons in human urine

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Abstract

An analytical method was developed to quantitatively determine selected monohydroxy metabolites of polycyclic aromatic hydrocarbons (PAHs) in human urine. The procedure included enzymatic hydrolysis to cleave the conjugated metabolites, solid-phase microextraction enrichment, and gas chromatography-mass spectrometry analysis. The method proved to be sensitive enough to detect the selected PAH metabolites in human urine.

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Authors and Affiliations

  1. Key Laboratory of Monitoring for Heavy Metal Pollutants, Hunan Province Environmental Monitoring Centre, Changsha, 410019, China

    Libin Liu, Yueping Luo & Junping Bi

  2. Beijing Key Laboratory of Microanalytical Methods and Instrumentation; Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Haifang Li & Jin-Ming Lin

Authors
  1. Libin Liu
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  2. Yueping Luo
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  3. Junping Bi
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  4. Haifang Li
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  5. Jin-Ming Lin
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Correspondence to Jin-Ming Lin.

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Liu, L., Luo, Y., Bi, J. et al. Quantification of selected monohydroxy metabolites of polycyclic aromatic hydrocarbons in human urine. Sci. China Chem. 58, 1579–1584 (2015). https://doi.org/10.1007/s11426-015-5357-2

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  • DOI: https://doi.org/10.1007/s11426-015-5357-2

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