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A new strategy to improve the sensitivity and selectivity of dopamine detection

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Abstract

We applied the combination of in situ electrochemical liquid-phase microextraction and square-wave voltammetric stripping analysis for the first time as a highly sensitive and selective approach for the detection of dopamine. A mixed gel of graphene sheets and an ionic liquid of 1-octyl-3-methylimidazolium hexaflurophosphate (OMimPF6) was used as a micro liquid-phase to pre-concentrate dopamine by controlled potential electrolysis from an aqueous solution (as a donor phase), followed by square-wave voltammetric stripping detection. Under optimized conditions, a linear calibration curve was obtained in the range of 0.05 to 1.0 μmol/L in the presence of excess ascorbic acid and uric acid. The detection limit has been found to be 8.0 nmol/L (S/N=3).

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences; College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China

    Jing Gu, Wenbo Zhao, Shujuan Liu, Yonghui Qiao, Xinyu Zhu, Xiaohong Yin, Zhiwei Zhu, Meixian Li & Yuanhua Shao

  2. Institute of Nuclear Chemistry and Physics, China Academy of Engineering Physics, Mianyang, 621900, China

    Xiang Xie

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  1. Xiang Xie
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  2. Jing Gu
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  3. Wenbo Zhao
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  5. Yonghui Qiao
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  6. Xinyu Zhu
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  7. Xiaohong Yin
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  8. Zhiwei Zhu
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  10. Yuanhua Shao
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Correspondence to Xiang Xie or Yuanhua Shao.

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Xie, X., Gu, J., Zhao, W. et al. A new strategy to improve the sensitivity and selectivity of dopamine detection. Sci. China Chem. 58, 892–898 (2015). https://doi.org/10.1007/s11426-014-5300-y

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  • DOI: https://doi.org/10.1007/s11426-014-5300-y

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