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Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities

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Abstract

Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3–5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.

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Acknowledgements

This work was financially supported by the Funds of NSFC-Jiangxi Province (No. 20161BAB204179), Jiangxi provincial education office (No. GJJ150407), and Post Doctoral in Jiangxi (No. 06292023).

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Authors and Affiliations

  1. Jiangxi Key Laboratory for Conservation and Utilization of Fungal Resources, Jiangxi Agricultural University, Nanchang, 330045, China

    Wenwen Peng & Guanghu Huo

  2. Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang, 330045, China

    Wenwen Peng & Dayong Peng

  3. College of Agriculture, Jiangxi Agricultural University, Nanchang, 330045, China

    Wenwen Peng, Lixia Zheng, Zhonghua Xiong & Xugen Shi

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  1. Wenwen Peng
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  2. Guanghu Huo
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  3. Lixia Zheng
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  4. Zhonghua Xiong
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  6. Dayong Peng
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Correspondence to Wenwen Peng.

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Peng, W., Huo, G., Zheng, L. et al. Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities. J Nat Med 73, 252–256 (2019). https://doi.org/10.1007/s11418-018-1244-4

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  • DOI: https://doi.org/10.1007/s11418-018-1244-4

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