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New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum

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Abstract

One atypical thiolane-type sulfide, garlicnin I2 (1), two 3,4-dimethylthiolane-type sulfides, garlicnins M (2) and N (3), and one thiabicyclic-type sulfide, garlicnin O (4), were isolated from the acetone extracts of Chinese garlic bulbs, Allium sativum and their structures were characterized. Hypothetical pathways for the production of the respective sulfides were discussed.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Sojo University, 4-22-2 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan

    Toshihiro Nohara & Tsuyoshi Ikeda

  2. School of Agriculture, Tokai University, 5435 Minamiaso, Aso, Kumamoto, 869-1404, Japan

    Masateru Ono, Naho Nishioka & Fuka Masuda

  3. Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan

    Yukio Fujiwara

  4. Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan

    Daisuke Nakano & Junei Kinjo

Authors
  1. Toshihiro Nohara
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  2. Masateru Ono
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  3. Naho Nishioka
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  4. Fuka Masuda
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  5. Yukio Fujiwara
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  6. Tsuyoshi Ikeda
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  7. Daisuke Nakano
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  8. Junei Kinjo
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Correspondence to Toshihiro Nohara.

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Nohara, T., Ono, M., Nishioka, N. et al. New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum . J Nat Med 72, 326–331 (2018). https://doi.org/10.1007/s11418-017-1133-2

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  • DOI: https://doi.org/10.1007/s11418-017-1133-2

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