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New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.

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Abstract

Four new diterpenoids (1–4), along with eight known diterpenoids (5–12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).

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Acknowledgments

This work was supported in part by MEXT-supported program for the Strategic Research Foundation at Private Universities and Keio Gijuku Academic Development Funds.

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Authors and Affiliations

  1. Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan

    Yuji Narukawa, Akiko Niimura, Hitomi Noguchi, Hiroomi Tamura & Fumiyuki Kiuchi

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  1. Yuji Narukawa
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  2. Akiko Niimura
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  3. Hitomi Noguchi
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  4. Hiroomi Tamura
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  5. Fumiyuki Kiuchi
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Correspondence to Fumiyuki Kiuchi.

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Narukawa, Y., Niimura, A., Noguchi, H. et al. New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.. J Nat Med 68, 125–131 (2014). https://doi.org/10.1007/s11418-013-0781-0

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  • DOI: https://doi.org/10.1007/s11418-013-0781-0

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