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Free-radical-scavenging principles from Phlomis caucasica

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Abstract

Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin (1), chrysoeriol 7-O-rutinoside (2), kaempferol 3-O-glucoside (3), chrysoeriol 7-O-glucoside (4) and naringenin (5), and two phenylethanoid glycosides, forsythoside B (6) and acteoside (7) were isolated from the methanol extract of the aerial parts of the Iranian medicinal plant Phlomis caucasica by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated by spectroscopic means. The free-radical-scavenging properties of 1–7 were assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay. Among these compounds, forsythoside B (6) and acteoside (7) were found to be the most potent antioxidants with the RC50 values of 4.97 and 4.27 μg/ml, respectively.

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Acknowledgments

We thank the EPSRC National Mass Spectrometry Service Centre (Department of Chemistry, University of Wales Swansea, Swansea, Wales, UK) for MS analyses.

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Authors and Affiliations

  1. School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Abbas Delazar, Araz Sabzevari, Mahdi Mojarrab, Hossein Nazemiyeh & Solmaz Esnaashari

  2. School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Co. Londonderry, UK

    Lutfun Nahar & Satyajit Dey Sarker

  3. Department of Biology, Faculty of Science, Mohagegeh Ardabili University, Ardabil, Iran

    Seied Mehdi Razavi

Authors
  1. Abbas Delazar
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  2. Araz Sabzevari
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  3. Mahdi Mojarrab
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  4. Hossein Nazemiyeh
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  5. Solmaz Esnaashari
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  6. Lutfun Nahar
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  7. Seied Mehdi Razavi
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  8. Satyajit Dey Sarker
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Correspondence to Satyajit Dey Sarker.

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Delazar, A., Sabzevari, A., Mojarrab, M. et al. Free-radical-scavenging principles from Phlomis caucasica . J Nat Med 62, 464–466 (2008). https://doi.org/10.1007/s11418-008-0255-y

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  • DOI: https://doi.org/10.1007/s11418-008-0255-y

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