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Antioxidant and hepatoprotective activity of the methanol extract of Careya arborea bark in Ehrlich ascites carcinoma-bearing mice

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Abstract

The methanol extract of Careya arborea bark (MECA) was tested for antioxidant and hepatoprotective activity in Ehrlich ascites carcinoma (EAC) tumor-bearing mice. Tumor control animals inoculated with EAC showed a significant alteration in the levels of antioxidant and hepatoprotective parameters. The extract treatment at 50, 100 and 200 mg/kg body weight doses given orally caused a significant reversal of these biochemical changes towards the normal in serum, liver and kidney when compared to tumor control animals indicating the potent antioxidant and hepatoprotective nature of the standardized extract.

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Acknowledgments

One of the authors (N.S.) thanks the All India Council of Technical Education, New Delhi for awarding a fellowship under QIP and S.H.D. thanks Department of Biotechnology, Government of India, New Delhi for awarding a junior research fellowship and a senior research fellowship.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Rock lands, Ootacamund, Tamil Nadu, 643 001, India

    Natesan Senthilkumar, Shrishailappa Badami, Santoshkumar H. Dongre & Suresh Bhojraj

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  1. Natesan Senthilkumar
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  2. Shrishailappa Badami
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  3. Santoshkumar H. Dongre
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  4. Suresh Bhojraj
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Correspondence to Shrishailappa Badami.

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Senthilkumar, N., Badami, S., Dongre, S.H. et al. Antioxidant and hepatoprotective activity of the methanol extract of Careya arborea bark in Ehrlich ascites carcinoma-bearing mice. J Nat Med 62, 336–339 (2008). https://doi.org/10.1007/s11418-008-0237-0

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  • DOI: https://doi.org/10.1007/s11418-008-0237-0

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