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Barrett – eine „never ending story“

Barrett – a never ending story

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Zusammenfassung

Verglichen mit anderen Tumoren des Gastrointestinaltraktes ist das Barrett-Karzinom zwar ein seltener Tumor, doch in den letzten Jahren zeigt sich eine ausgeprägte Zunahme der Inzidenz. Noch nicht abschließend geklärt ist die Entstehung der Barrett-Schleimhaut. Die Molekularpathologie hat wichtige molekulare Mechanismen und epigenetische Veränderungen der Barrett-Schleimhaut auf dem Weg zum Karzinom aufgedeckt. Insgesamt muss man jedoch festhalten, dass es durch die Vielfalt der Prozesse, die an der Karzinogenese beteiligt sind, schwierig ist, die Entstehung der Barrett-Neoplasie so auf molekularer Ebene zu interpretieren, dass diese Erkenntnisse auch für die tägliche Routine nutzbar sind.

Abstract

In comparison to other tumors of the gastrointestinal tract, Barrett’s carcinoma is in fact a rare entity, but it has exhibited a pronounced increase in incidence in recent years. The development of Barrett’s mucosa has not yet been conclusively clarified. Research in the field of molecular pathology has revealed important molecular mechanisms and epigenetic alterations of Barrett’s mucosa leading to carcinoma. On the whole, however, it must be noted that due to the variety of processes involved in carcinogenesis it is difficult to interpret the development of Barrett’s neoplasia at the molecular level to the extent that these insights are also useful for everyday routine practice.

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Authors and Affiliations

  1. Institut für Pathologie, Klinikum Bayreuth, Preuschwitzer Str. 101, 95445, Bayreuth, Deutschland

    M. Vieth

  2. Institut für Pathologie, Ruhr-Universität Bochum, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Deutschland

    A. Tannapfel

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  1. M. Vieth
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  2. A. Tannapfel
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Correspondence to M. Vieth or A. Tannapfel.

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Vieth, M., Tannapfel, A. Barrett – eine „never ending story“. Gastroenterologe 3, 316–322 (2008). https://doi.org/10.1007/s11377-008-0194-x

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