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Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study

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Abstract

Cardiovascular disease and frailty frequently occur together. Both are associated with inflammation, which may be partially triggered by oxidative stress, especially in cardiovascular disease. We investigated whether inflammatory and oxidative stress biomarkers linked to cardiovascular disease were associated with frailty and the related outcome of gait speed. We report cross-sectional associations of biomarkers and frailty assessed at Framingham Offspring Study cycle eight. Participants ≥60 years were eligible if they had information on frailty and at least one of the following: C-reactive protein, interleukin-6, tumor necrosis factor receptor 2, 8-epi-FGFα isoprostanes (isoprostanes), lipoprotein phospholipase A2 (LpPLA2) mass or activity, osteoprotegerin, intracellular adhesion molecule-1, monocyte chemoattractant protein-1 or P-selectin. Stepwise logistic models were utilized for frailty and stepwise linear models for gait speed. Covariates included age, sex, body mass index, smoking, and co-morbidities. Odds ratios (ORs) and slope estimates (B) are reported per standard deviation increase of loge-transformed biomarker. Of the 1919 participants, 142 (7 %) were frail. In a stepwise model, frailty odds increased with higher interleukin-6 (OR 1.90, 95 % CI 1.51, 2.38), isoprostanes (OR 1.46, 95 % CI 1.12, 1.92), and LpPLA2 mass (OR 1.29, 95 % CI 1.00, 1.65). Stepwise regression found that slower gait speeds were associated with interleukin-6 (B = −0.025 m/s, 95 % CI 0.04, −0.01), isoprostanes (B = −0.019, 95 % CI −0.03, −0.008), LpPLA2 mass (B = −0.016, 95 % CI −0.03, −0.004), and osteoprotegerin (B = −0.015, 95 % CI −0.03, −0.002, all p < 0.05). Interleukin-6, isoprostanes, and LpPLA2 mass were associated with greater frailty odds and slower gait speeds. Oxidative stress may be a mechanism contributing to frailty.

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Acknowledgments

We thank Emily Abrams for her assistance. The investigators are indebted to Framingham Offspring Study participants and staff. Lipoprotein-associated phospholipase A2 activity measurements were provided by GlaxoSmithKline and mass measurements by diaDexus at no cost. This was presented at the Annual Meeting of the American Geriatrics Society in Grapevine, TX, May 3–5, 2013. Correspondence should be addressed to Dr. Christine Liu, Boston Medical Center, 88 East Newton Street, Robinson 2, Boston, MA, 02118 or Christine.Liu@bmc.org.

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Authors and Affiliations

  1. Section of Geriatrics, Department of Medicine, Boston University School of Medicine, 88 E Newton Street, Robinson 2, Boston, MA, 02118, USA

    Christine K. Liu

  2. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Christine K. Liu

  3. National Heart, Lung and Blood Institute’s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA, 01702, USA

    Asya Lyass, Martin G. Larson, Joseph M. Massaro, Ralph B. D’Agostino Sr, Emelia J. Benjamin & Joanne M. Murabito

  4. Department of Mathematics and Statistics, Boston University, Boston, MA, USA

    Asya Lyass, Martin G. Larson, Na Wang & Ralph B. D’Agostino Sr

  5. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

    Martin G. Larson & Joseph M. Massaro

  6. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA

    Emelia J. Benjamin

  7. Sections of Cardiovascular and Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA

    Emelia J. Benjamin

  8. Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA

    Joanne M. Murabito

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  1. Christine K. Liu
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Correspondence to Christine K. Liu or Joanne M. Murabito.

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Funding

This work was supported by the National Institute on Aging (grant number R01-AG029451 to JM Murabito, 1R01-AG028321 to EJB) and by the National Heart, Lung and Blood Institute (grant number 1RO1-HL64753, R01-HL076784 to EJB), both at the National Institutes of Health. The Framingham Heart Study is supported by the National Heart, Lung, and Blood Institute in collaboration with Boston University (contract number N01-HC-25195). CKL was supported by the American Federation for Aging Research, the John A. Hartford Foundation, and the U.S. Department of Agriculture, under Agreement no. 1950-51000-068-01S.

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Liu, C.K., Lyass, A., Larson, M.G. et al. Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study. AGE 38, 1 (2016). https://doi.org/10.1007/s11357-015-9864-z

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