Abstract
Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories earlier in life affect the residual life span distribution. We used longitudinal limited access data from seven physiological indices and life spans of respective individuals collected in the Framingham Heart Study (FHS). These include: diastolic blood pressure (DBP), pulse pressure (PP), body mass index (BMI), serum cholesterol (SCH), blood glucose (BG), hematocrit (HC), and pulse rate (PR). We developed a method for assigning individuals to groups of potentially long-lived (PLL) and potentially medium-lived (PML) groups using age trajectories of physiological indices at the age interval between 40 and 60 years. The analysis shows that the longevity of individuals who survived to age of 65 depends on the behavior of the physiological indices between 40 and 60 years of age.
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Abbreviations
- BG:
-
blood glucose
- BMI:
-
body mass index
- CVD:
-
cardiovascular disease
- DBP:
-
diastolic blood pressure
- FHS:
-
the Framingham Heart Study
- HC:
-
hematocrit
- LL:
-
long-lived
- ML:
-
medium-lived
- PLL:
-
potentially long-lived
- PML:
-
potentially medium-lived
- PP:
-
pulse pressure
- PR:
-
pulse rate
- SCH:
-
serum cholesterol
- SL:
-
short-lived
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Acknowledgements
The Framingham Heart Study (FHS) is conducted and supported by the NHLBI in collaboration with FHS Investigators. This manuscript was prepared using a limited access dataset obtained by the NHLBI and does not necessarily reflect the opinions or views of the FHS or the NHLBI. The work on this project was partly supported by the NIH/NIA grants 1R01 AG028259-01, 1RO1-AG-027019-01 and 5PO1-AG-008761-16.
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Yashin, A.I., Akushevich, I.V., Arbeev, K.G. et al. Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study. AGE 28, 363–374 (2006). https://doi.org/10.1007/s11357-006-9023-7
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DOI: https://doi.org/10.1007/s11357-006-9023-7