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Matricidal hatching can induce multi-generational effects in nematode Caenorhabditis elegans after dietary exposure to nanoparticles

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Abstract

In this study, we investigated multi-generational effects and generation particle transfer in Caenorhabditis elegans following maternal food exposure to core-shell quantum dots. We found that that the Bag of Worms (BOW) phenotype in aged worms induces changes in quantum dot distribution in the parental body, which is related to the inter-generation transfer of these nanoparticles and to their effects in the offspring. To confirm these results we examined a variety of endpoints, namely, survival, reproduction, aging phenotype, oxidative stress, and intestinal fat metabolism. We show that worms born to parents at different times after exposure show different phenotypic effects as a consequence of quantum dot transfer. This evidence of trans-generational transfer and the effects of nanoparticles highlights the complex multi-generational effects and potential safety hazards that can occur under real environmental conditions.

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Acknowledgements

We thank Prof. Yhong Hee Shim (Konkuk University) and Prof. Junho Lee (Seoul National University) for providing the C. elegans strains.

Funding

This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (2016R1A2B3010445, 2016M3A6A7945504). This work also was supported by Korea Environment Industry & Technology Institute through “The Chemical Accident Prevention Technology Development Project”, funded by Korea Ministry of Environment (No. 2016001970001).

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Authors and Affiliations

  1. Department of Environmental Health Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea

    Shin Woong Kim, Jongmin Moon & Youn-Joo An

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  1. Shin Woong Kim
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  2. Jongmin Moon
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  3. Youn-Joo An
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Correspondence to Youn-Joo An.

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Responsible editor: Philippe Garrigues

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Kim, S.W., Moon, J. & An, YJ. Matricidal hatching can induce multi-generational effects in nematode Caenorhabditis elegans after dietary exposure to nanoparticles. Environ Sci Pollut Res 25, 36394–36402 (2018). https://doi.org/10.1007/s11356-018-3535-4

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  • DOI: https://doi.org/10.1007/s11356-018-3535-4

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