Abstract
Dimethylformamide (DMF) is a broad solvent used in the production of synthetic leather. Decades of year's research have been focused on workers in leather factories suffering from the release of DMF. However, little attention was paid on general population. Here, we examined the relationship between consistent DMF exposure and annual hospitalizations of local residents in Longwan, China, in 2008. We found a positive correlation with a relative risk (RR) increase of 1.110 for total hospitalizations. When the data were stratified by sex, we observed a higher correlation for female hospitalizations than for male hospitalizations, with RR values of 1.55 and 1.084, respectively. This might be attributed to the differences in genotypes of oxidant enzyme between gender. The significance of the correlations did not disappear after we excluded the extreme value of DMF or adjusted for SO2, NO2, and PM10. Population living near the leather factory has experienced almost constant DMF exposure, and real concern should be raised regarding such exposure. Governments should take responsibility for the protection of not only occupational workers but also residents, especially women.
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References
Abbey DE, Nishino N, Mcdonnell WF, Burchette RJ et al (1999) Long-term inhalable particles, and other air pollutants related to mortality in nonsmokers. Am J Respir Crit Care Med 159:373–382
Chang CT, Lin KL (2006) Assessment of the strategies for reducing VOCs emission from polyurea-formaldehyde resin synthetic fiber leather industry in Taiwan. Resour Conserv Recycl 46:321–334
Chang HY, Shih TS, Guo YL et al (2004) Sperm function in workers exposed to N,N-dimethylformamide in the synthetic leather industry. Fertil Steril 81:1589–1594
Giada A, Emanuela G, Vincenzo L et al (2001) Oxidation of N,N-dimethylformamide and N,N-diethylformamide by human liver microsomes and human recombinant P450s. Toxicol Lett 124:11–19
Hajat S, Haines A, Atkinson RW et al (2001) Association between air pollution and daily consultations with general practitioners for allergic rhinitis in London, United Kingdom. Am J Epidemiol 153:704–714
Hamada M, Abe M, Tokumoto Y et al (2009) Occupational liver injury due to N,N-dimethylformamide in the synthetics industry. Intern Med 48:1647–1650
Hideke S, Shigetoshi A, Heihachiro A et al (2004) Carcinogenicity and chronic toxicity after in halation exposure of rats and mice to N,N-dimethylformamide. J Occup Health 46:429–439
Japan Society for Occupational Health (2002) Recommendation of occupational exposure limits (2001–2002). J Occup Health 44:267–282
Kennedy GL (1986) Biological effects of acetamide, formamide and their monomethyl and dimethyl derivatives. Crit Rev Toxicol 17:129–182
Lee KY, Byeon JH, Song HR et al (2003) Seasonal variations of the urinary N-methylformamide concentration among workers at a synthetic leather factory. Korean J Occup Environ Med 15:162–172
Luo JC, Cheng TJ, Kuo HW et al (2005) Abnormal liver function associated with occupational exposure to dimethylformamide and glutathione S-transferase polymorphisms. Biomarkers 10:464–474
Lynch DW, Placke ME, Persing RL et al (2003) Thirteen-week inhalation toxicity of N,N-dimethylformamide in F344/N rats and B6C3F1 mice. Toxicol Sci 72:347–358
Ministry of Labor (2002) Exposure criteria for chemical substances and physical agents in the workplace. Ministry of Labor, Republic of Korea
Nomiyama T, Nakashima H, Sano Y, Chen LL et al (2001) Does the polymorphism of cytochrome P-450 2E1 affect the metabolism of N,N -dimethyformamide. Arch Toxicol 74:755–759
Peters JM, Avol E, Gauderman WJ et al (1999) A study of twelve Southern California communities with differing levels and types of air pollution. Am J Respir Crit Care Med 159:768–775
Pham-Huu-Chanh, Azum-Gelade MC, Van Bac N et al (1973) Cardiovascular activity of N,N-dimethylformamide. Toxicology 1:135–141
Sang BK, Bong SC, Jong KP (2002) The metabolism and liver toxicity of N,N -dimethylformamide in the isolated perfused rat liver. Yonsei Med J 43:491–499
Shieh DB, Chen CC, Shih TS et al (2007) Mitochondrial DNA alterations in blood of the humans exposed to N,N -dimethylformamide. Chem Biol Interact 165:211–219
Wang RS, Nakajima T, Honma T (1999) Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat. Ind Health 37:440–448
Wang C, Tian WL, Wei YM et al (2013) Study on the association between residential exposure to N,N-dimethylformamide and hospitalization for respiratory disease. Atmos Environ 77:166–171
Wei YM, Tian WL, Zhang QY et al (2011a) Evaluating population exposure to N,N-dimethylformamide in a small industrial area accounting for population movement. J Zhejiang Univ Sci A 12:794–806
Wei YM, Tian WL, Zheng YY et al (2011b) Modelling of urban ambient N,N-dimethylformamide concentrations in a small-scale synthetic leather industrial zone. J Zhejiang Univ Sci A 12:374–389
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This work was partially financed by the National Natural Science Funds of China (no. 21307110) and State Environmental Protection Commonweal Trade Scientific Research Project of the Ministry of Environmental Protection of the People's Republic of China (no. 200809103).
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Zhang, Q., Huang, C., Wei, Y. et al. Risk assessment of N,N-dimethylformamide on residents living near synthetic leather factories. Environ Sci Pollut Res 21, 3534–3539 (2014). https://doi.org/10.1007/s11356-013-2336-z
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DOI: https://doi.org/10.1007/s11356-013-2336-z