Skip to main content
Log in

Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea: a HuGE review and meta-analysis

Sleep and Breathing Aims and scope Submit manuscript

Abstract

Background

Several epidemiological studies have been conducted to examine the association between leptin and leptin receptor (LEPR) gene polymorphisms and risk of obstructive sleep apnea (OSA). However, the results remain conflicting rather than conclusive.

Objective

The aim of this study was to investigate associations of leptin and LEPR polymorphisms and risk of OSA.

Methods

We carried out a search in MEDLINE, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases for relevant studies. Data were extracted using a standardized form and pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to assess the strength of the association.

Results

Overall, no statistically significant association of OSA risk and polymorphisms of Gln233Arg, Lys109Arg, Lys656Asn, 19A/G, Pro1019Arg, and 2548G/A was found. However, in the stratified analysis by ethnicity, Gln233Arg polymorphism was associated with a significantly decreased risk of OSA in European (homozygote comparison: OR = 0.35, 95 % CI = 0.14–0.85, P = 0.02), but not for Asian population.

Conclusions

Our study suggested that leptin and LEPR polymorphisms had no association with OSA risk in all examined patients, whereas there was an association between Gln233Arg polymorphism and OSA risk in Europeans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Wang Q, Wu Q, Feng J, Sun X (2013) Obstructive sleep apnea and endothelial progenitor cells. Patient Prefer Adherence 7:1077–1090

    PubMed Central  PubMed  Google Scholar 

  2. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S (1993) The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328:1230–1235

    Article  CAS  PubMed  Google Scholar 

  3. Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G (2013) Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol 62:569–576

    Article  PubMed Central  PubMed  Google Scholar 

  4. Paz-Filho G, Mastronardi CA, Licinio J (2014) Leptin treatment: facts and expectations. Metabolism In press.

  5. Akilli H, Kayrak M, Bekci TT, Erdogan Hİ, Aribas A, Yildirim O, Taner A, Erer M, Unlu A (2014) Gender-related changes of the epicardial fat thickness and leptin in obstructive sleep apnea. Echocardiography 31:411–419

    Article  PubMed  Google Scholar 

  6. Macrea M, Martin T, Zagrean L, Jia Z, Misra H (2013) Role of leptin as antioxidant in obstructive sleep apnea: an in vitro study using electron paramagnetic resonance method. Sleep Breath 17:105–110

    Article  PubMed  Google Scholar 

  7. Ulukavak Ciftci T, Kokturk O, Bukan N, Bilgihan A (2005) Leptin and ghrelin levels in patients with obstructive sleep apnea syndrome. Respiration 72:395–401

    Article  CAS  PubMed  Google Scholar 

  8. Patel SR, Palmer LJ, Larkin EK, Jenny NS, White DP, Redline S (2004) Relationship between obstructive sleep apnea and diurnal leptin rhythms. Sleep 27:235–239

    PubMed  Google Scholar 

  9. Gao C, Liu Y, Liu X, Li H (2011) Polymorphism of leptin +19A/G and risk of obstructive sleep apnea syndrome. Shandong Med J 51:36–37

    CAS  Google Scholar 

  10. Huang R, Huang X, Li M, Xiao Y, Zhang J (2003) An investigation of the relationship between Lepr gene Gln223Arg polymorphism and obstructive sleep apnea hypopnea syndrome. Chin J Tuberc Respir Dis 26:517–521

    CAS  Google Scholar 

  11. Popko K, Gorska E, Wasik M, Stoklosa A, Pływaczewski R, Winiarska M, Gorecka D, Sliwinski P, Demkow U (2007) Frequency of distribution of leptin receptor gene polymorphism in obstructive sleep apnea patients. J Physiol Pharmacol 58:551–561

    PubMed  Google Scholar 

  12. Tan Y (2008) The relation between leptin receptor gene Gln223Arg polymorphism and obstructive sleep apnea-hypopnea syndrome. Dissertation, Hebei Medical University

  13. Hanaoka M, Yu X, Urushihata K, Ota M, Fujimoto K, Kubo K (2008) Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea syndrome. Chest 133:79–85

    Article  CAS  PubMed  Google Scholar 

  14. Han L (2012) Relationship between serum Leptin, polymorphism of Leptin gene 2548G/A, leptin receptor gene Gln223Arg and correlation to obstructive sleep apnea hypopnea syndrome. Dissertation, Hebei United University

  15. Liu Y, Gao C, Wang L, Li H, Jia J (2013) The correlational study on polymorphisms of leptin receptor genes Lysl09Arg and Pro1019Pro and obstructive sleep apnea hypopnea syndrome. Chin J Mod Med 23:36–40

    CAS  Google Scholar 

  16. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) The PRISMA Group (2009) preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097

    Article  PubMed Central  PubMed  Google Scholar 

  17. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283:2008–2012

    Article  CAS  PubMed  Google Scholar 

  18. Cao C, Wang R, Wang J, Bunjhoo H, Xu Y, Xiong W (2012) Body mass index and mortality in chronic obstructive pulmonary disease: a meta-analysis. PLoS One 7:e43892

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. Cao C, Wang J, Bunjhoo H, Xu Y, Fang H (2012) Risk profile of bevacizumab in patients with non-small cell lung cancer: a meta-analysis of randomized controlled trials. Acta Oncol 51:151–156

    Article  CAS  PubMed  Google Scholar 

  20. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560

    Article  PubMed Central  PubMed  Google Scholar 

  21. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Mishra HK, Sharma SK, Sreenivas V (2013) Angiotensin-converting enzyme gene polymorphism in north Indian population with obstructive sleep apnea. Sleep Breath 17:1029–1037

    Article  CAS  PubMed  Google Scholar 

  23. Chen W, Ye J, Han D, Yin G, Wang B, Zhang Y (2012) Association of prepro-orexin polymorphism with obstructive sleep apnea/hypopnea syndrome. Am J Otolaryngol 33:31–36

    Article  PubMed  Google Scholar 

  24. Ogus C, Ket S, Bilgen T, Keser I, Cilli A, Gocmen AY, Tosun O, Gumuslu S (2010) Insertion/deletion polymorphism and serum activity of the angiotensin-converting enzyme in Turkish patients with obstructive sleep apnea syndrome. Biochem Genet 48:516–523

    Article  CAS  PubMed  Google Scholar 

  25. Koyama RG, Drager LF, Lorenzi-Filho G, Cintra FD, Pereira AC, Poyares D, Krieger JE, Castro RM, Tufik S, de Mello MT, Pedrazzoli M (2009) Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males. Sleep Med 10:1107–1111

    Article  PubMed  Google Scholar 

  26. Bhushan B, Guleria R, Misra A, Luthra K, Vikram NK (2009) TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea. Respir Med 103:386–392

    Article  PubMed  Google Scholar 

  27. Almpanidou P, Hadjigeorgiou G, Gourgoulianis K, Papadimitriou A (2012) Association of tumor necrosis factor-α gene polymorphism (−308) and obstructive sleep apnea-hypopnea syndrome. Hippokratia 16:217–220

    PubMed Central  CAS  PubMed  Google Scholar 

  28. Ding Q, Cao C, Chen Z, Tabusi M, Chen L, Deng Z (2014) A functional EGF + 61 polymorphism is associated with severity of obstructive sleep apnea. Sleep Breath In press.

Download references

Acknowledgments

This work was supported by grant of the Natural Science Foundation of Ningbo (No. 2012A610257, Z Deng) and the Program of Medical Research of Ningbo (2013A19).

Conflicts of interest

We declare that we have no conflicts of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zaichun Deng.

Additional information

The authors Dan Lv and Lin Tan contributed equally to this study.

Dan Lv and Lin Tan contributed equally to this work.

Electronic supplementary material

Below is the link to the electronic supplementary material.

ESM 1

(DOC 68 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lv, D., Tan, L., Wu, Y. et al. Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea: a HuGE review and meta-analysis. Sleep Breath 19, 1073–1078 (2015). https://doi.org/10.1007/s11325-015-1120-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11325-015-1120-3

Keywords

Navigation