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On the Usage of Brain Atlases in Neuroimaging Research

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Abstract

Brain atlases play a key role in modern neuroimaging analysis of brain structure and function. We review available atlas databases for humans and animals and illustrate common state-of-the-art workflows in neuroimaging research based on image registration. Advances in noninvasive imaging methods, 3D ex vivo microscopy, and image processing are summarized which will eventually close the current resolution gap between brain atlases based on conventional 2D histology and those based on 3D in vivo imaging.

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Acknowledgements

The writing of this review was initiated by the members of the Molecular Neuroimaging Study Group of the European Society for Molecular Imaging (ESMI). We gratefully thank the ESMI for their support and the possibility of establishing the study group as a platform for scientific exchange within the society and beyond.

Funding

This work is supported by the Deutsche Forschungsgemeinschaft (DFG Cluster of Excellence NeuroCURE, Exc 257 to P.B-S.), the German Federal Ministry of Education and Research (BMBF; 01EO0801, Center for Stroke Research Berlin to P.B-S. and BMBF NeuroRad (02NUK034D to A.H.), BMBF NeuroImpa (01EC1403C) to A.H.), INCF Digital Atlasing program to A.H., the Research Foundation - Flanders (FWO G048917N to R.H. and G.A.K.), and Flagship ERA-NET (FLAG-ERA) FUSIMICE (grant agreement G.0D7651N to R.H. and G.A.K.).

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Authors and Affiliations

  1. Institute for Experimental Pharmacology, Friedrich Alexander University Erlangen Nuremberg, Fahrstraße 17, 91054, Erlangen, Germany

    Andreas Hess

  2. Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium

    Rukun Hinz & Georgios A. Keliris

  3. Department of Experimental Neurology and Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany

    Philipp Boehm-Sturm

  4. NeuroCure Cluster of Excellence and Charité Core Facility 7T Experimental MRIs, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Philipp Boehm-Sturm

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  1. Andreas Hess
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  2. Rukun Hinz
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  3. Georgios A. Keliris
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  4. Philipp Boehm-Sturm
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Correspondence to Andreas Hess or Philipp Boehm-Sturm.

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Hess, A., Hinz, R., Keliris, G.A. et al. On the Usage of Brain Atlases in Neuroimaging Research. Mol Imaging Biol 20, 742–749 (2018). https://doi.org/10.1007/s11307-018-1259-y

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