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Histogram Analysis of T1-Weighted, T2-Weighted, and Postcontrast T1-Weighted Images in Primary CNS Lymphoma: Correlations with Histopathological Findings—a Preliminary Study

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Abstract

Purpose

Previously, some reports mentioned that magnetic resonance imaging (MRI) can predict histopathological features in primary CNS lymphoma (PCNSL). The reported data analyzed diffusion-weighted imaging findings. The aim of this study was to investigate possible associations between histopathological findings, such as tumor cellularity, nucleic areas and proliferation index Ki-67, and signal intensity on T1-weighted and T2-weighted images in PCNSL.

Procedures

For this study, 18 patients with PCNSL were retrospectively investigated by histogram analysis on precontrast and postcontrast T1-weighted and fluid-attenuated inversion recovery (FLAIR) images. For every patient, histopathology parameters, nucleic count, total nucleic area, and average nucleic area, as well as Ki-67 index, were estimated.

Results

Correlation analysis identified several statistically significant associations. Skewness derived from precontrast T1-weighted images correlated with Ki-67 index (p = − 0.55, P = 0.028). Furthermore, entropy derived from precontrast T1-weighted images correlated with average nucleic area (p = 0.53, P = 0.04). Several parameters from postcontrast T1-weighted images correlated with nucleic count: maximum signal intensity (p = 0.59, P = 0.017), P75 (p = 0.56, P = 0.02), and P90 (p = 0.52, P = 0.04) as well as SD (p = 0.58, P = 0.02). Maximum signal intensity derived from FLAIR sequence correlated with nucleic count (p = 0.50, P = 0.03).

Conclusion

Histogram-derived parameters of conventional MRI sequences can reflect different histopathological features in PSNCL.

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Abbreviations

ADC:

Apparent diffusion coefficient

DCE:

Dynamic contrast-enhanced MRI

DWI:

Diffusion-weighted imaging

PCNSL:

Primary CNS lymphoma

ROI:

Region of interest

SI:

Signal intensity

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Author notes

  1. Hans-Jonas Meyer and Stefan Schob contributed equally to this work.

Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, University Leipzig, Liebigstraße 20, 04103, Leipzig, Germany

    Hans-Jonas Meyer, Benno Münch, Nikita Garnov & Alexey Surov

  2. Department of Neuroradiology, University Hospital Leipzig, Leipzig, Germany

    Stefan Schob, Ulf Quäschling & Karl-Titus Hoffmann

  3. Department of Neuropathology, University Hospital Leipzig, Leipzig, Germany

    Clara Frydrychowicz

Authors
  1. Hans-Jonas Meyer
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  2. Stefan Schob
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  3. Benno Münch
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  4. Clara Frydrychowicz
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  8. Alexey Surov
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Correspondence to Hans-Jonas Meyer.

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Meyer, HJ., Schob, S., Münch, B. et al. Histogram Analysis of T1-Weighted, T2-Weighted, and Postcontrast T1-Weighted Images in Primary CNS Lymphoma: Correlations with Histopathological Findings—a Preliminary Study. Mol Imaging Biol 20, 318–323 (2018). https://doi.org/10.1007/s11307-017-1115-5

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  • DOI: https://doi.org/10.1007/s11307-017-1115-5

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