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Complete genomic sequence of the goat prion protein gene (PRNP)

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Abstract

Prion protein genetics plays a central role in transmissible spongiform encephalopathies, a disease occurring in human and animals. Here we report a 27-kb genomic sequence containing the goat PRNP gene. It shows, both in structure and content, a remarkable similarity with its sheep ortholog and can serve as a basis for future (comparative) studies with reference to the regulation of PRNP gene expression and the search for genetic tools to prevent/control/eradicate (goat) TSE.

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Abbreviations

BAC:

Bacterial artificial chromosome

BSE:

Bovine spongiform encephalopathy

CDS:

Complete coding sequence

EU:

European Union

PRNP :

Gene encoding endogenous prion protein

LINE:

Long interspersed elements

LTR:

Long terminal repeats

SINE:

Short interspersed elements

TSE:

Transmissible spongiform encephalopathy

UTR:

Untranslated region

vCJD:

Variant Creutzfeldt-Jakob disease

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Acknowledgments

The authors wish to thank Dominique Vander Donckt, Linda Impe, and Ruben Van Gansbeke for the excellent technical assistance and dedication. This work was supported by FPS Health, Food Chain Safety and Environment (Project S-6151/70).

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Authors and Affiliations

  1. Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, 9820, Merelbeke, Belgium

    Mario Van Poucke, Nicolas Willemarck, Alex Van Zeveren & Luc J. Peelman

  2. Laboratoire de Radiobiologie et d’Etude du Génome, CRB GADIE, INRA, 78352, Jouy-en-Josas, France

    Karine Hugot

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  1. Mario Van Poucke
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  2. Nicolas Willemarck
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  3. Karine Hugot
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Corresponding author

Correspondence to Mario Van Poucke.

Additional information

The nucleotide sequence data reported in this paper has been submitted to the GenBank nucleotide sequence database and has been assigned the accession number EU870890.

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Van Poucke, M., Willemarck, N., Hugot, K. et al. Complete genomic sequence of the goat prion protein gene (PRNP). Virus Genes 38, 189–192 (2009). https://doi.org/10.1007/s11262-008-0288-z

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  • DOI: https://doi.org/10.1007/s11262-008-0288-z

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