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Relationship between erectile dysfunction and moderate to severe prostatitis-like symptoms in middle-aged men: a propensity score–matched analysis

  • Urology - Original Paper
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Abstract

Purpose

We assessed the relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) using propensity score matching.

Methods

Data from 8727 middle-aged men who had undergone health checkups were analyzed. The National Institutes of Health Chronic Prostatitis Symptoms Index (NIH-CPSI), the International Index of Erectile Function-5 (IIEF), the Premature Ejaculation Diagnostic Tool (PEDT), testosterone measurement, basic blood chemistry, and metabolic syndrome (MetS) assessment were performed in this study. Of the 8727 men considered, 7181 formed the cohort for propensity score matching, including 597 men with moderate to severe prostatitis-like symptoms (case) and 6584 men with no prostatitis-like symptoms (control); ultimately, however, members of the case and control groups were matched at a 1:1 ratio by propensity score.

Results

After matching, the variables of age, testosterone, PEDT and MetS were evenly distributed between the groups. After matching, the mean IIEF score of the case group was significantly lower than that of the control group (17.2 ± 5.5 vs. 14.7 ± 5.3; P < 0.001). Additionally, the severity of ED was significantly greater in the case group (no, mild, mild to moderate, moderate, and severe, respectively: 27.5%, 30.2%, 24.6%, 13.1%, and 4.7% in the control group; 10.7%, 27.0%, 33.0%, 18.9%, and 10.4% in the case group; P < 0.001). Finally, the rate of moderate to severe ED was significantly higher in the case group than in the control group (17.8% vs. 29.3%; P < 0.001).

Conclusion

Moderate to severe prostatitis-like symptoms were significantly and independently correlated with ED in middle-aged men.

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Acknowledgements

We thank Hye Young Han from Nowon Eulji Medical Center Library for manuscript’s technical editing and Springer Nature for language editing.

Funding

No funding was received to assist with the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Urology, Nowon Eulji Medical Center, Eulji University School of Medicine, 327, Gongneung-ro, Nowon-gu, Seoul, 01830, Republic of Korea

    Jun Ho Lee, Tag Keun Yoo, Jung Yoon Kang, Sin Woo Lee & Jae Duck Choi

  2. Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu-si, Republic of Korea

    Jeong Man Cho

  3. Department of Urology, National Police Hospital, Seoul, South Korea

    Yeon Won Park

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  1. Jun Ho Lee
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Contributions

JDC conceptualized the study. JHL and JDC designed the study. TKY, SWL, and JMC collected the original data. JYK performed the statistical analysis of the data. JDC and JHL performed the writing of the article.

Corresponding author

Correspondence to Jae Duck Choi.

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Conflict of interest

The authors have declared that they have no conflicts of interest.

Ethical approval

This study was approved by Nowon Eulji Medical Center, Eulji University School of Medicine Ethical Committee, Seoul, South Korea. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

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Lee, J.H., Yoo, T.K., Kang, J.Y. et al. Relationship between erectile dysfunction and moderate to severe prostatitis-like symptoms in middle-aged men: a propensity score–matched analysis. Int Urol Nephrol 53, 2261–2266 (2021). https://doi.org/10.1007/s11255-021-02991-8

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