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Cardiovascular risk independently predicts small functional bladder storage capacity

  • Urology - Original Paper
  • Published:
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Abstract

Purpose

We aimed to determine the potential relationship between atherosclerotic cardiovascular disease (ASCVD) score, which equates to 10-year risk of atherosclerotic cardiovascular events, and functional bladder capacity (FBC) among men in the outpatient urology setting.

Methods

We secondarily analyzed voiding diaries from men aged 40 to 79 years with nocturia. Patients with a history of cardiovascular disease or who had nocturnal polyuria were excluded. Patients were stratified by whether they met the high-risk ASCVD threshold (≥ 20%) following current cardiology consensus guidelines and assessed for the presence of small FBC (24-h maximum voided volume ≤ 200 ml). Logistic regression analyses were employed to explore associations between small FBC and ASCVD.

Results

Eighty-four men (median ASCVD score 18.4 [IQR 12.8–26.9] %, age 66 [61–71] years, body mass index [BMI] 29.4 [26.4–32.7] kg/m2) were included, of whom 36 (42.9%) were high-risk and 48 (57.1%) fell below the high-risk threshold. High-risk patients were more likely to have small FBC (23 [63.9%] vs. 14 [29.2%], p = 0.002). ASCVD risk predicted small FBC on univariate analysis (p = 0.002). No such effect was observed with age (p = 0.116), BMI (p = 0.523), or benign prostatic obstruction (p = 0.180). The association between ASCVD risk and small FBC persisted on multivariate analysis after controlling for BMI and benign prostatic obstruction (p = 0.002). No significant predictors of small FBC were observed when age, a major determinant of ASCVD risk and independent correlate of small FBC, was substituted for ASCVD score (p = 0.108).

Conclusions

Small FBC is related to a higher predicted cardiovascular event rate in men with nocturia.

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The present analysis involved routinely collected institutional data.

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Funding

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Author information

Author notes

  1. Thomas F. Monaghan and Jason M. Lazar contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Box 79, Brooklyn, NY, 11203, USA

    Thomas F. Monaghan, Connelly D. Miller, Christina W. Agudelo, Syed N. Rahman & Jeffrey P. Weiss

  2. Department of Urology, Ghent University Hospital, Ghent, Belgium

    Karel Everaert

  3. Departments of Medicine and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Lori A. Birder

  4. Division of Urology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Alan J. Wein

  5. Division of Cardiovascular Medicine, Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Jason M. Lazar

Authors
  1. Thomas F. Monaghan
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Contributions

TM conceptualization—equal, data curation—equal, formal analysis—equal, investigation—lead, methodology—equal, resources—lead, software—lead, validation—lead, visualization—lead, writing—original draft—lead, writing—review and editing—equal. CM and CA data curation—equal, writing—review and editing—supporting. SR, KE, LB and AW writing—review and editing—supporting. JW data curation—equal, resources—equal, writing—review and editing—supporting. JL conceptualization—equal, data curation—equal, formal analysis—equal, methodology—equal, writing—original draft—supporting, writing—review and editing—equal.

Corresponding author

Correspondence to Thomas F. Monaghan.

Ethics declarations

Conflict of interest

Thomas F. Monaghan has no direct or indirect commercial incentive associated with publishing this article and certifies that all conflicts of interest relevant to the subject matter discussed in the manuscript are the following: Karel Everaert is a consultant and lecturer for Medtronic and Ferring and reports institutional grants from Allergan, Ferring, Astellas, and Medtronic, outside the submitted work. Lori A. Birder is a consultant for Ferring, Urogen, and Allergan, outside the submitted work. Alan J. Wein has served as an advisor/consultant for Bulkamid, Medtronic, Serenity, Urovant, and Velicept, outside the submitted work. Jeffrey P. Weiss is a consultant for Ferring, and the Institute for Bladder and Prostate Research, outside the submitted work. The additional authors have nothing to disclose.

Ethical approval

A nocturnal voiding database was compiled with approval from the Veterans Affairs New York Harbor Healthcare System Institutional Review Board. A waiver of informed consent was granted.

Informed consent

A waiver of informed consent was obtained. All authors have approved the final version of the submission and consent to publication of the present manuscript.

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Monaghan, T.F., Miller, C.D., Agudelo, C.W. et al. Cardiovascular risk independently predicts small functional bladder storage capacity. Int Urol Nephrol 53, 35–39 (2021). https://doi.org/10.1007/s11255-020-02616-6

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  • DOI: https://doi.org/10.1007/s11255-020-02616-6

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