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Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Purpose

Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients.

Materials and methods

Seventy-one non-dialysis CKD patients with low vitamin D (serum 25(OH)D < 30 ng/mL) were recruited. Patients received oral cholecalciferol 50,000 units once a week for 12 weeks. Changes in endothelial function by brachial artery flow-mediated dilation (FMD), soluble vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin were studied.

Results

There was a significant increase in serum levels of 25(OH)D after cholecalciferol supplementation (33.7 ± 12.1 vs. 13.2 ± 5.4 ng/mL, P < 0.001). Multivariable regression analysis showed that higher proteinuria (β = − 0.548, P < 0.001) and lower levels of 25(OH)D (β = 0.360, P < 0.001) at baseline were related to lower 25(OH)D level after supplementation. FMD increased significantly from 4.4 ± 1.3 to 5.1 ± 1.5% (P < 0.001), and soluble endothelial biomarkers decreased: sVCAM-1 from 926.9 ± 158.0 to 867.0 ± 129.0 ng/mL (P < 0.001), and sE-selectin 69.7 ± 15.8 to 63.3 ± 14.7 ng/mL (P < 0.001).

Conclusions

Vitamin D supplementation can improve endothelial dysfunction in pre-dialysis CKD patients.

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Funding

This study was funded by the National Natural Science Foundation of China (81500537).

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Authors and Affiliations

  1. Department of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, 321 Zhong Shan Road, Nanjing, 210008, China

    Qingyan Zhang, Miao Zhang, Hengjin Wang, Cheng Sun, Yuan Feng, Wei Zhu, Dongwei Cao, Qiuyuan Shao, Nan Li, Yangyang Xia, Tianfeng Tang, Cheng Wan, Jing Liu, Bo Jin, Min Zhao & Chunming Jiang

Authors
  1. Qingyan Zhang
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  2. Miao Zhang
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  3. Hengjin Wang
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  4. Cheng Sun
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  5. Yuan Feng
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  6. Wei Zhu
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  7. Dongwei Cao
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  8. Qiuyuan Shao
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  9. Nan Li
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  10. Yangyang Xia
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  11. Tianfeng Tang
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  12. Cheng Wan
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  13. Jing Liu
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  14. Bo Jin
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  15. Min Zhao
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  16. Chunming Jiang
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Corresponding author

Correspondence to Chunming Jiang.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Cite this article

Zhang, Q., Zhang, M., Wang, H. et al. Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease. Int Urol Nephrol 50, 923–927 (2018). https://doi.org/10.1007/s11255-018-1829-6

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  • DOI: https://doi.org/10.1007/s11255-018-1829-6

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