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The impact of fish oil and wheat germ oil combination on mineral-bone and inflammatory markers in maintenance hemodialysis patients: a randomized, double-blind, placebo-controlled clinical trial

  • Nephrology - Original Paper
  • Published:
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Abstract

Purpose

This study aimed to examine the impact of combined supplementation of fish oil (FO) with antioxidants like wheat germ oil (WGO) on mineral-bone and inflammatory markers in maintenance HD patients.

Methods

This randomized, double-blind, placebo-controlled trial involved 46 HD patients who were randomly assigned into two groups to receive daily 3000 mg of FO [1053 mg omega-3 fatty acids (ω-3 FAs)] plus 300 mg of WGO [0.765 mg vitamin E] or placebo for 4 months. Blood concentrations of hemoglobin (Hgb), white blood cells, mineral-bone parameters including serum calcium (Ca), phosphorus, calcium–phosphorus product, parathyroid hormone, alkaline phosphatase, and osteoprotegerin and serum concentrations of inflammatory markers including high-sensitivity C-reactive protein, ferritin, and uric acid were measured before and after the intervention.

Results

Eighty-seven percentage of patients in each group completed the study. The mean serum Ca levels increased significantly in the supplemented group at the end of study (p = 0.0016), and this increment was also significant as compared to placebo group (p = 0.0418). No significant alterations were observed in the other measured parameters within each group during the study (as p values were >0.05).

Conclusion

FO plus WGO supplementation showed beneficial effect on serum Ca levels of HD patients without any statistically significant effect on other mineral-bone and inflammatory markers. Further investigations are required to confirm it.

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Acknowledgements

The authors would like to thank Sedico Pharmaceutical Company, Egypt, for providing both placebo and Omega-3 plus® soft-gel capsules free of charge. The authors also acknowledge the great efforts and contributions of all staff members of the hemodialysis unit of Mansoura University Hospital and all participants in this study since without them, this study would have never been accomplished.

Author information

Authors and Affiliations

  1. Department of Pharmacy, Mansoura Fever Hospital, Mansoura, Egypt

    Hadeer Zakaria

  2. Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta, Egypt

    Tarek M. Mostafa & Gamal A. El-Azab

  3. Department of Internal Medicine, Faculty of Medicine, Mansoura, Egypt

    Ahmed M. Abd El Wahab & Nagy AH Sayed-Ahmed

  4. Department of Clinical Pathology, Faculty of Medicine, Mansoura, Egypt

    Heba Elshahawy

Authors
  1. Hadeer Zakaria
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  2. Tarek M. Mostafa
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  3. Gamal A. El-Azab
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  4. Ahmed M. Abd El Wahab
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  5. Heba Elshahawy
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  6. Nagy AH Sayed-Ahmed
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Corresponding author

Correspondence to Hadeer Zakaria.

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Conflict of interest

All the authors declare no conflict of interest in this work.

Ethical approval

The study protocol was approved by the institutional research board (IRB) of Mansoura University (Code number: MS/15.09.34). All participants signed a written informed consent before the start of the study.

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Zakaria, H., Mostafa, T.M., El-Azab, G.A. et al. The impact of fish oil and wheat germ oil combination on mineral-bone and inflammatory markers in maintenance hemodialysis patients: a randomized, double-blind, placebo-controlled clinical trial. Int Urol Nephrol 49, 1851–1858 (2017). https://doi.org/10.1007/s11255-017-1643-6

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  • DOI: https://doi.org/10.1007/s11255-017-1643-6

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