Skip to main content
Log in

Bilateral renal cancers: oncological and functional outcomes

International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Purpose

The authors assessed the characteristics of bilateral renal cancers.

Methods

From January 1995 to January 2015, 65 patients underwent surgery for bilateral renal cancers. Thirty-four of the patients had 36 synchronous tumors, while the remaining 29 had metachronous tumors. The mean age of the patients was 60 ± 11 years. There were 22 females and 43 males. In all cases, bilateral partial nephrectomies or unilateral nephrectomy and contralateral nephron-sparing surgery were performed.

Results

The mean sizes of the synchronous tumors were 5.0 ± 2.7 and 4.7 ± 3.0 cm at the first and the second operations, respectively. The average diameters of the metachronous carcinomas were 6.6 ± 3.0 and 3.1 ± 1.6 cm at the initial and the second surgeries, respectively. Histologic concordance was 91.1 % in the synchronous and 96.5 % in the metachronous tumors. The mean postoperative creatinine levels increased by 116 %, while the GFR decreased by 44.8 % in synchronous tumors at the second operation. The mean postoperative creatinine levels increased by 42 %, while the GFR decreased by 30.4 % in metachronous carcinomas at the second operation. The mean follow-up time was 4.8 ± 3.7 years. During this period, distant metastases occurred in two patients with synchronous tumors and in six cases with metachronous tumors. Local recurrences were detected in one case of synchronous tumor and in four patients with metachronous carcinomas. The 5-year overall and tumor-specific survivals were 53 and 80 %, respectively.

Conclusions

In patients with bilateral renal carcinomas, the histologic concordance was 93.6 %. The bilateral partial nephrectomies or unilateral nephrectomy and contralateral resection provided acceptable oncological and functional outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Patel MI, Simmons R, Kattan MW, Motzer RJ, Reuter VE, Russo E (2003) Long-term follow-up of bilateral sporadic renal tumors. Urology 61:921–925

    Article  PubMed  Google Scholar 

  2. Bratslavsky G, Linehan WM (2010) Long-term management of bilateral, multifocal, recurrent renal carcinoma. Nat Rev Urol 7(5):267–275

    Article  PubMed  PubMed Central  Google Scholar 

  3. Heintz J, Berkowitz J, Sausville J, Phelan M (2011) Combined nephron-sparing techniques for the management of bilateral synchronous renal masses. Urology 77(4):772–774

    Article  PubMed  Google Scholar 

  4. Zhang S, Zhao X, Ji C, Liu G, Li X, Zhang G, Gan W, Guo H (2012) Radiofrequency ablation of synchronous bilateral renal cell carcinoma. Int J Urol 19(3):241–247

    Article  CAS  PubMed  Google Scholar 

  5. Becker F, Siemer S, Tzavaras A, Suttmann H, Stoeckle M (2008) Long-term survival in bilateral renal cell carcinoma: a retrospective single-institutional analysis of 101 patients after surgical treatment. Urology 72(2):349–353

    Article  PubMed  Google Scholar 

  6. Blute ML, Itano NB, Cheville JC, Weaver AL, Lohse CM, Zincke H (2003) The effect of bilaterality, pathological features and surgical outcome in nonhereditary renal cell carcinoma. J Urol 169:1276–1281

    Article  PubMed  Google Scholar 

  7. Pahernik S, Cudovic D, Roos F, Melchior SW, Thüroff JW (2007) Bilateral synchronous sporadic renal cell carcinoma: surgical management, oncological and functional outcomes. BJU Int 100:26–29

    Article  PubMed  Google Scholar 

  8. Boorjian SA, Crispen PL, Lohse CM, Leibovich BC, Blute ML (2008) The impact of temporal presentation on clinical and pathological outcomes for patients with bilateral renal masses. Eur Urol 54:855–863

    Article  PubMed  Google Scholar 

  9. Booth J, Matin SF, Ahrar K, Tamboli P, Wood CG (2008) Contemporary strategies for treating nonhereditary synchronous bilateral renal tumors and the impact of minimally invasive, nephron-sparing techniques. Urol Oncol 26(1):37–42

    Article  PubMed  Google Scholar 

  10. Klatte T, Patard JJ, Wunderlich H, Goel RH, Lam JS, Junker K, Schubert J, Böhm M, Allhoff EP, Kabbinavar FF, Crepel M, Cindolo L, De La Taille A, Tostain J, Mejean A, Soulie M, Bellec L, Bernhard JC, Ferriere JM, Pfister C, Albouy B, Colombel M, Zisman A, Belldegrun AS, Pantuck AJ (2007) Metachronous bilateral renal cell carcinoma: risk assessment, prognosis and relevance of the primary-free interval. J Urol 177(6):2081–2086

    Article  PubMed  Google Scholar 

  11. Patel AR, Lee BH, Campbell SC, Zhou M, Fergany AF (2011) Bilateral synchronous sporadic renal tumors: pathologic concordance and clinical implications. Urology 78(5):1095–1099

    Article  PubMed  Google Scholar 

  12. Rothman J, Crispen PL, Wong YN, Al-Saleem T, Fox E, Uzzo RG (2008) Pathologic concordance of sporadic synchronous bilateral renal masses. Urology 72(1):138–142

    Article  PubMed  PubMed Central  Google Scholar 

  13. Richstone L, Scherr DS, Reuter VR, Snyder ME, Rabbani F, Kattan MW, Russo P (2004) Multifocal renal cortical tumors: frequency, associated clinicopathological features and impact on survival. J Urol 171:615–620

    Article  PubMed  Google Scholar 

  14. Simmons MN, Brandina R, Hernandez AV, Gill IS (2010) Surgical management of bilateral synchronous kidney tumors: functional and oncological outcomes. J Urol 184:865–872

    Article  PubMed  Google Scholar 

  15. Woodson B, Fernandez R, Stewart C, Mandava S, Wang L, Lee BR (2013) Bilateral synchronous sporadic renal masses: intermediate functional and oncological outcomes at a single institution. Int Urol Nephrol 45(3):619–625

    Article  PubMed  Google Scholar 

  16. Singer EA, Vourganti S, Lin KY, Gupta GN, Pinto PA, Rastinehad AR, Linehan WM, Bratslavsky G (2012) Outcomes of patients with surgically treated bilateral renal masses and a minimum of 10 years of followup. J Urol 188:2084–2088

    Article  PubMed  Google Scholar 

  17. Novick AC, Streem S, Montie JE, Pontes JE, Siegel S, Montague DK, Goormastic M (1989) Conservative surgery for renal cell carcinoma: a single-center experience with 100 patients. J Urol 141:835–839

    CAS  PubMed  Google Scholar 

  18. Marberger M, Pugh RC, Auvert J, Bertermann H, Costantini A, Gammelgaard PA, Petterson S, Wickham JE (1981) Conservation surgery of renal carcinoma: the EIRSS experience. Br J Urol 53:528–532

    Article  CAS  PubMed  Google Scholar 

  19. Amano H, Kondo T, Hashimoto Y, Kobayashi H, Iizuka J, Shimada K, Nakazawa H, Ito H, Tanabe K (2010) Contralateral metachronous tumor occurrence is more frequently associated with distant metastases or postoperative intrarenal recurrence in renal cell carcinoma patients. Int J Urol 17:615–622

    Article  PubMed  Google Scholar 

  20. Siemer S, Uder M, Zell A, Pönicke C, Humke U, Ziegler M, Stöckle M (2001) Bilateral kidney tumor. Therapy management and histopathological results with long-term follow-up of 66 patients. Urol A 40:114–120

    Article  CAS  Google Scholar 

  21. Zincke H, Swanson SK (1982) Bilateral renal cell carcinoma: influence of synchronous and asynchronous occurrence on patient survival. J Urol 128:913–915

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Csaba Berczi.

Ethics declarations

Conflict of interest

The authors have no conflict of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Berczi, C., Thomas, B., Bacso, Z. et al. Bilateral renal cancers: oncological and functional outcomes. Int Urol Nephrol 48, 1617–1622 (2016). https://doi.org/10.1007/s11255-016-1354-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11255-016-1354-4

Keywords

Navigation