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A clinicopathological study of renal biopsies from 288 elderly patients: analysis based on 4,185 cases

  • Nephrology - Original Paper
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Abstract

Purpose

To investigate the clinical characteristics and histopathological features of kidney disease in elderly patients.

Methods

We retrospectively analyzed the results of 4,185 consecutive renal biopsies, and 288 patients aged >60 years at the Second Hospital of Jilin University from January 1998 to December 2013 were finally included. All patients had been clinically and histologically diagnosed with kidney disease.

Results

Nephrotic syndrome was the main clinical indication for biopsy. Twenty-four patients (8.33 %) experienced a minor complication related to their biopsy procedure. Among patients diagnosed as primary glomerulonephritis (GN), membranous nephropathy (MN) was the most frequent subclassification (24.7 %), followed by mesangioproliferative glomerulonephritis (MsPGN, 11.1 %) and IgA nephropathy (IgAN, 8.0 %). Amyloidosis (8.7 %) was the most common secondary GN, followed by antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune GN (5.2 %) and diabetic nephropathy (DN, 3.8 %). Based on renal biopsies results, 143/288 patients received immunosuppressive therapy and showed an overall remission rate (complete plus partial remissions) of 74.1 %. Among 71 MN patients, 29 patients received steroids plus cyclophosphamide and showed a remission rate of 79.3 %, while 42 patients received steroids and tacrolimus and showed a remission rate of 90.5 %. Among 25 patients with amyloidosis, 22 cases received melphalan plus dexamethasone and showed a remission rate of 40.9 %, while three patients received vincristine, adriamycin, and dexamethasone and showed a remission rate of 66.7 %.

Conclusion

Making an accurate pathologic diagnosis by renal biopsy is crucial for selecting the proper treatment for elderly patients with kidney disease.

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Acknowledgments

The authors would like to express their gratitude to all the physicians participated in this study. This study was supported by the Science and Technology Foundation of Jilin Province (20130206056SF), the Director Funds of the National Natural Science Foundation of China (81241023), the Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (No. 2011BAI10B05), the National Natural Science Foundation of China (No. 81202348), Jiangsu Province National Natural Science Funds (No. BK2012171), and the Natural Science Research Project of Higher Education of Jiangsu (No. 12KJD310006).

Conflict of interest

None.

Author information

Authors and Affiliations

  1. The Department of Nephropathy, The Second Hospital, Norman Bethune Medical College, Jilin University, Changchun, 130021, China

    Fan Yang, Wenpeng Cui, Shujun Liu, Qiaoyan Guo, Man Wu, Lining Miao & Ping Luo

  2. The Department of Nephropathy, Jilin Province People’s Hospital, Changchun, China

    Bing Li

  3. The Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China

    Chunyan He

Authors
  1. Fan Yang
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  2. Bing Li
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  3. Wenpeng Cui
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  4. Chunyan He
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  5. Shujun Liu
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  6. Qiaoyan Guo
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  7. Man Wu
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  8. Lining Miao
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  9. Ping Luo
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Corresponding author

Correspondence to Ping Luo.

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Yang, F., Li, B., Cui, W. et al. A clinicopathological study of renal biopsies from 288 elderly patients: analysis based on 4,185 cases. Int Urol Nephrol 47, 327–333 (2015). https://doi.org/10.1007/s11255-014-0895-7

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  • DOI: https://doi.org/10.1007/s11255-014-0895-7

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