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Podocytes proliferate: novel mechanism identified in collapsing glomerulopathies

  • Nephrology - Translational Section
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Fig. 1

References

  1. Ronconi E, Sagrinati C, Angelotti ML, Lazzeri E, Mazzinghi B, Ballerini L, Parente E, Becherucci F, Gacci M, Carini M, Maggi E, Serio M, Vannelli GB, Lasagni L, Romagnani S, Romagnani P (2009) Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 20(2):322–332

    Article  PubMed  CAS  Google Scholar 

  2. Smeets B, Angelotti ML, Rizzo P, Dijkman H, Lazzeri E, Mooren F, Ballerini L, Parente E, Sagrinati C, Mazzinghi B, Ronconi E, Becherucci F, Benigni A, Steenbergen E, Lasagni L, Remuzzi G, Wetzels J, Romagnani P (2009) Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. J Am Soc Nephrol 20(12):2593–2603

    Article  PubMed  Google Scholar 

  3. Shkreli M, Sarin KY, Pech MF, Papeta N, Chang W, Brockman SA, Cheung P, Lee E, Kuhnert F, Olson JL, Kuo CJ, Gharavi AG, D’Agati VD, Artandi SE (2012) Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med 18(1):111–119

    Article  CAS  Google Scholar 

  4. Kriz W (1996) Progressive renal failure–inability of podocytes to replicate and the consequences for development of glomerulosclerosis. Nephrol Dial Transplant 11(9):1738–1742

    Article  PubMed  CAS  Google Scholar 

  5. Shankland SJ, Pippin JW, Reiser J, Mundel P (2007) Podocytes in culture: past, present, and future. Kidney Int 72(1):26–36

    Article  PubMed  CAS  Google Scholar 

  6. Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC (2005) Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 16(10):2941–2952

    Article  PubMed  CAS  Google Scholar 

  7. Kim YH, Goyal M, Kurnit D, Wharram B, Wiggins J, Holzman L, Kershaw D, Wiggins R (2001) Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 60(3):957–968

    Article  PubMed  CAS  Google Scholar 

  8. Cohen AH, Mampaso F, Zamboni L (1977) Glomerular podocyte degeneration in human renal disease: an ultrastructural study. Lab Investig 37(1):30–42

    PubMed  CAS  Google Scholar 

  9. Barisoni L, Kriz W, Mundel P, D’Agati V (1999) The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 10(1):51–61

    PubMed  CAS  Google Scholar 

  10. Barisoni L, Mokrzycki M, Sablay L, Nagata M, Yamase H, Mundel P (2000) Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int 58(1):137–143

    Article  PubMed  CAS  Google Scholar 

  11. Wang S, Kim JH, Moon KC, Hong HK, Lee HS (2004) Cell-cycle mechanisms involved in podocyte proliferation in cellular lesion of focal segmental glomerulosclerosis. Am J Kidney Dis 43(1):19–27

    Article  PubMed  CAS  Google Scholar 

  12. Martinez P, Blasco MA (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 11(3):161–176

    Article  PubMed  CAS  Google Scholar 

  13. Atasoy P, Yilmaz E, Bozdogan O, Ayva S, Batislam E (2009) Expression profile and prognostic importance in prostate lesions of the reverse transcriptase component of human telomerase (hTERT) and of cyclin-dependent kinase inhibitor p57 (p57kip2a). Int Urol Nephrol 41(1):55–60

    Article  PubMed  CAS  Google Scholar 

  14. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781–810

    Article  PubMed  CAS  Google Scholar 

  15. Nusse R (2008) Wnt signaling and stem cell control. Cell Res 18(5):523–527

    Article  PubMed  CAS  Google Scholar 

  16. Waters A, Koziell A (2009) Activation of canonical Wnt signaling meets with podocytopathy. J Am Soc Nephrol 20(9):1864–1866

    Article  PubMed  Google Scholar 

  17. Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y (2009) Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 20(9):1997–2008

    Article  PubMed  CAS  Google Scholar 

  18. Wang D, Dai C, Li Y, Liu Y (2011) Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria. Kidney Int 80(11):1159–1169

    Article  PubMed  CAS  Google Scholar 

  19. Simons M, Huber TB (2011) Old friends form alliance against podocytes. Kidney Int 80(11):1117–1119

    Article  PubMed  CAS  Google Scholar 

  20. Sarin KY, Cheung P, Gilison D, Lee E, Tennen RI, Wang E, Artandi MK, Oro AE, Artandi SE (2005) Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436(7053):1048–1052

    Article  PubMed  CAS  Google Scholar 

  21. Choi J, Southworth LK, Sarin KY, Venteicher AS, Ma W, Chang W, Cheung P, Jun S, Artandi MK, Shah N, Kim SK, Artandi SE (2008) TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet 4(1):e10

    Article  PubMed  Google Scholar 

  22. D’Agati VD, Kaskel FJ, Falk RJ (2012) Focal segmental glomerulosclerosis. N Engl J Med 365(25):2398–2411

    Article  Google Scholar 

  23. Schell C, Huber TB (2012) New players in the pathogenesis of focal segmental glomerulosclerosis. Nephrol Dial Transplant (in press)

  24. Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K (2011) Wnt/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 286(29):26003–26015

    Article  PubMed  CAS  Google Scholar 

  25. Zhu C, Mertens PR (2010) Epithelial-mesenchymal transition to be or not to be? Is the answer yes and no at the same time? Int Urol Nephrol 42(3):843–846

    Article  PubMed  Google Scholar 

  26. Taneda S, Honda K, Uchida K, Nitta K, Yumura W, Oda H, Nagata M (2012) Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis. Int Urol Nephrol 44(1):183–196

    Article  PubMed  Google Scholar 

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Acknowledgments

PRM is funded by SFB854, TP1 and ME1365/7-1.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany

    Cheng Zhu & Peter R. Mertens

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  1. Cheng Zhu
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  2. Peter R. Mertens
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Correspondence to Peter R. Mertens.

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Zhu, C., Mertens, P.R. Podocytes proliferate: novel mechanism identified in collapsing glomerulopathies. Int Urol Nephrol 45, 275–279 (2013). https://doi.org/10.1007/s11255-012-0318-6

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  • DOI: https://doi.org/10.1007/s11255-012-0318-6

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