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Optimized outcomes for renal allografts with cold ischemic times of 20 h or greater

  • Urology - Original Paper
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Abstract

Background

Prolonged cold ischemia time (CIT) has been associated with inferior graft survival in kidney transplantation (KT). The aim of this study was to evaluate the impact of prolonged CIT on short- and long-term outcomes and to determine the possible ways to optimize the use of these organs.

Methods

All kidney transplants from April 2001 to December 2010 with CIT ≥ 20 h were considered. Donor and recipient data were analyzed with uni- and multivariate Cox proportional hazard analyses. Graft and patient survival were calculated using the Kaplan–Meier method.

Results

One hundred and eighty-one patients were transplanted with 184 grafts. Median recipient age and waiting time on dialysis were 52.5 and 4.9 years, respectively. After a median follow-up of 4.9 years, 148 of 181 patients are alive, 143 of them with functioning grafts. One-, three, and five-year graft and patient survival rates were 90, 87, and 79 %, and 96, 91, and 85 %, respectively. Donor age (p < 0.0001), retransplantation (p = 0.0025), and induction therapy with interleukin-2 antagonists (p = 0.0487) were predictors of graft survival by univariate analysis. Donor age and retransplantation remained significant by multivariate analysis (p < 0.001 and p = 0.0046, respectively). Donor age (p = 0.0176) and creatinine level at 1-month post-KT (p = 0.0271) were predictors of patient survival by univariate analysis. Only donor age reached multivariate significance (p = 0.0464). The calculated donor age cut off was 60 years.

Conclusions

Satisfactory long-term kidney transplant outcomes in the setting of CIT ≥ 20 h can be achieved with grafts from donors <60 years in first-time recipients. Induction therapy should preferably be with an interleukin-2 antagonist.

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Abbreviations

CIT:

Cold ischemic time

CMV:

Cytomegalovirus

CPR:

Cardiopulmonary resuscitation

DGF:

Delayed graft function

HTK:

Histidine–Tryptophane–Ketoglutarate

ICU:

Intensive care unit

IGF:

Immediate graft function

KLF2:

Krüppel–like factor 2

KT:

Kidney transplantation

ROC:

Receiver operating characteristic

UW:

University of Wisconsin

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Authors and Affiliations

  1. Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany

    Anja Gallinat, Andreas Paul, Jürgen W. Treckmann & Georgios C. Sotiropoulos

  2. Department of Nephrology, University Hospital Essen, Essen, Germany

    Oliver Witzke

  3. Division of Surgical Research, Clinic of Surgery, University of Bonn, Bonn, Germany

    Thomas Minor

  4. Department of Surgery, North Shore University Hospital, Manhasset, NY, USA

    Ernesto P. Molmenti

Authors
  1. Anja Gallinat
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  2. Andreas Paul
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  3. Thomas Minor
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  4. Jürgen W. Treckmann
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  5. Ernesto P. Molmenti
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  6. Oliver Witzke
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  7. Georgios C. Sotiropoulos
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Corresponding author

Correspondence to Georgios C. Sotiropoulos.

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Gallinat, A., Paul, A., Minor, T. et al. Optimized outcomes for renal allografts with cold ischemic times of 20 h or greater. Int Urol Nephrol 44, 1417–1423 (2012). https://doi.org/10.1007/s11255-012-0235-8

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  • DOI: https://doi.org/10.1007/s11255-012-0235-8

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