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High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients

  • Nephrology - Original Paper
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Abstract

Purpose

We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients.

Methods

SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method.

Results

sUA among survivors (112.1 ± 13.82 μmol/L) was significantly lower than in deceased (160.8 ± 16.81 μmol/L, p < 0.001), while SOD was higher in survivors (31.8 ± 6.61 kU/L) than among deceased (20.2 ± 3.03, p < 0.05). Kaplan–Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (≥127.11 μmol/L, p < 0.001), and for SOD in the lowest tertile (≤23.83 kU/L, p < 0.05).

Conclusion

Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.

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Acknowledgments

This work was supported by grants from the Ministry of Education and Science, Republic of Serbia (Projects No. 175023 and 175035).

Conflict of interest

None.

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Authors and Affiliations

  1. Center for Clinical Laboratory Diagnostics, Clinical Center of Montenegro, Podgorica, Montenegro

    Tanja Antunovic, Najdana Gligorovic-Barhanovic & Dragica Bozovic

  2. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11152, Belgrade, Serbia

    Aleksandra Stefanovic, Jasmina Ivanisevic & Marina Stojanov

  3. Clinic for Urology and Nephrology, Clinical Center of Montenegro, Podgorica, Montenegro

    Marina Ratkovic & Branka Gledovic

  4. Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Milica Prostran

Authors
  1. Tanja Antunovic
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  2. Aleksandra Stefanovic
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  3. Marina Ratkovic
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  4. Branka Gledovic
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  9. Marina Stojanov
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Corresponding author

Correspondence to Aleksandra Stefanovic.

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Antunovic, T., Stefanovic, A., Ratkovic, M. et al. High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. Int Urol Nephrol 45, 1111–1119 (2013). https://doi.org/10.1007/s11255-012-0233-x

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  • DOI: https://doi.org/10.1007/s11255-012-0233-x

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