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Novel techniques and newer markers for the evaluation of “proximal tubular dysfunction”

  • Nephrology – Review
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Abstract

Renal Fanconi syndromes are both clinically challenging and physiologically fascinating. The diagnosis requires a certain index of suspicion to correctly identify the clinical symptomatology and pursue the appropriate laboratory evaluations. The renal Fanconi syndrome (FS) is a defect of proximal tubular function attributable to different rare inherited diseases or acquired disorders caused by a multitude of exogenous agents. It can manifest as complete or incomplete FS, characterized by low molecular weight proteinuria, glucosuria, aminoaciduria, and loss of electrolytes, bicarbonate and lactate. Implementation of new methods and recent findings from urinary proteome pattern in patients with renal FS has led to the identification of new markers for proximal tubular dysfunction. Future combined proteomic and metabonomic studies will provide additional potential biomarkers and may help to gain novel insights in the diagnosis and differentiation of the various forms of FS. Moreover, the observation of poor renal uptake of 99 mTc-DMSA in patients with tubular proteinuria, which is not fully understood yet, may also help to elucidate the individual basis of FS in early stages. This review focuses on the new advances in the evaluation of proximal tubular dysfunction in various forms of Fanconi syndrome.

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Authors and Affiliations

  1. Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany

    Michael Ludwig

  2. Department of Pediatrics, PGIMER and Associated RML Hospital, New Delhi, India

    Sidharth K. Sethi

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  1. Michael Ludwig
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  2. Sidharth K. Sethi
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Correspondence to Sidharth K. Sethi.

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Ludwig, M., Sethi, S.K. Novel techniques and newer markers for the evaluation of “proximal tubular dysfunction”. Int Urol Nephrol 43, 1107–1115 (2011). https://doi.org/10.1007/s11255-011-9914-0

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