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Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature

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Abstract

Renal involvement in paroxysmal nocturnal hemoglobinuria (PNH) is usually clinically not apparent but, in cases with clinical involvement, varies from reversible acute dysfunction to chronic irreversible damage. We report two cases of acute kidney injury and one case of chronic kidney disease due to PNH. In all three cases a diagnosis of PNH was made after detection of renal dysfunction. The renal involvement was documented on both histology and on imaging studies. Finally, we briefly review the main literature data on renal involvement in PNH.

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Authors and Affiliations

  1. Department of Nephrology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India

    R. K. Nair, Ambar Khaira & Sandeep Mahajan

  2. Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India

    Alok Sharma & Amit K. Dinda

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  1. R. K. Nair
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  2. Ambar Khaira
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  3. Alok Sharma
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  4. Sandeep Mahajan
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  5. Amit K. Dinda
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Correspondence to Alok Sharma.

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Nair, R.K., Khaira, A., Sharma, A. et al. Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature. Int Urol Nephrol 40, 471–475 (2008). https://doi.org/10.1007/s11255-008-9356-5

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  • DOI: https://doi.org/10.1007/s11255-008-9356-5

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